Abstract:
Objective: To evaluate the e cacy and safety of eribulin plus anti-angiogenic medicine in metastatic breast cancer (MBC), and explore the potential biomarkers. Study Design: Observational study. Place and Duration of the Study: Department of Medical Oncology, Xi an International Medical Centre Hospital, Xi an, China, from May 2022 to 2023. Methodology: A total of 40 MBC patients treated with eribulin were enrolled. Patients were divided into two groups based on whether they received eribulin monotherapy or combined therapy. Median progression-free survival(mPFS), the time from the start of erbium treatment to the time of disease progression, was calculated using the Kaplan-Meier method. Results: The eribulin plus anti-angiogenic medicine treatment group had a significantly prolonged mPFS compared to the group without anti-angiogenic medicine treatment (7.0 months vs. 2.0 months, p <0.001). The multivariate analysis identi ed that the combination of anti-angiogenic therapy (HR = 0.043, p = 0.004) and the occurrence of grade 3-4 neutropenia after the treatment were two predictive factors for longer PFS (HR = 0.322, p = 0.009). In contrast, prior resistance to taxane was predictive of shorter PFS (HR = 4.583, p = 0.019). Other clinic-pathological factors were not significantly associated with PFS. Fisher's exact test showed no significant increase in treatment-related adverse events (all grades) after combination with anti-angiogenic medicine. Conclusion: The eribulin plus anti-angiogenic combination may act as a potential therapy for late-line MBC patients with clinically beneficial therapeutic effects.
Keywords:
Eribulin
,
Antiangiogenic therapy
,
Predictive indicators of e cacy
,
Metastatic Breast Cancer