Alpha-Glucosidase inhibitory constituents from Ficus bengalensis. | [Pakistan Journal of Chemistry • 2015]

Author(s):

1. M. A. Naveed: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

2. N. Riaz: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

3. M. Saleem: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

4. B. Jabeen: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

5. M. Ashraf: Department of Biochemistry & Biotechnology, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

6. U. Alam: Department of Biochemistry & Biotechnology, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

7. A. Jabbar: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Abstract:

Chromatographic purification of the methanolic extract of the aerial roots of Ficus bengalensis resulted the purifiaction of 3β- acetoxyurs-9,(11),12-diene ,(1), a new triterpene together with lupeol ,(2), lupeol acetate ,(3), conrauidienol ,(4), β-sitosterol ,(5), alpinum isoflavone ,(6), methyl 4-hydroxybenzoate ,(7), 4-hydroxymellein ,(8), 4-hydroxybenzoic acid ,(9), p-coumaric acid ,(10), oleanolic acid ,(11) and β-sitosterol 3-O-β-D-glucopyranoside ,(12). These compounds ,(1-12) were characterized by using 1D- ,( 1H, 13C) and 2D-NMR ,(HMQC, HMBC, COSY, NOESY) spectroscopy and mass spectrometry ,(EI-MS, HR-EI-MS, FAB-MS, HRFAB-MS), and in comparison with the data reported for related compounds in literature. These isolates ,(1-12) showed inhibitory activity against enzyme α-glucosidase with IC50 values ranging between 26.3-297.7 µM.

Page(s): 42-48

DOI: DOI not available

Published: Journal: Pakistan Journal of Chemistry, Volume: 5, Issue: 1, Year: 2015

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