Alteration in the level of total cholesterol by steroidal molecules on cerebrum, cerebellum and brain stem of albino rats. | [Hamdard Medicus • 2005]

Author(s):

1. Ehtsham H. Khan: Steroid Research Laboratory, Department of Chemistry, AMU, Aligarh, India

2. Sheeba Shafi: Department of Pharmacy, College of Health Sciences, Dammam, Kingdom of Saudi Arabia

3. S. J. Rizvi: Interdisciplinary Brain Research Center (IBRC), J.N. Medical College, Aligarh Muslim University, Aligarh, (UP.), India

Abstract:

Changes in the level of Cholesterol on albino rat’s brain (Cerebrum, Cerebellum and brain stem) were evaluated following the administration of four steroidal compounds as 3β-Acetoxy-5-bromo-6β hydroxy-5α-Cholestane A (I), 3β-Acetoxy-6-dimethyl amino-Cholest-5-ene B (II), 3β Chloro-5 bromo, 6β nitro-5α-Cholestane C (Ill) and 6β-Amino pyrimidino-Cholest4en-3-one D (IV). Experiments were carried out on four groups of six male albino rats weighing 200±20 gm. Control albino rats were administered saline solution intraperitoneally (ip), while the other experimental groups were given 0.3 mg/kg body weight of steroidal solutions which was prepared in peanut oil.

Page(s): 152-156

DOI: DOI not available

Published: Journal: Hamdard Medicus, Volume: 48, Issue: 1, Year: 2005

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