Abstract:
Peganum harmala is a member of the Zygophyllaceae family that grows wild throughout the Middle East and North Africa. Syrian rue or Harmal is the common name for P. harmala. P. harmala extracts are relevant for drug development because they have been documented to have wide variety of pharmacological properties in Iran and Egypt. P. harmala is being used in conventional medicine for pain alleviation and as an antiseptic for a long time. P. harmala seeds contain a high concentration of therapeutically useful alkaloids known as harmala alkoids. The goal of this research is to assess the antibacterial and antidiabetic effectivity of silver nanoparticles, copper nanoparticles, and zinc oxide nanoparticles prepared using a cost-effective green chemistry method with P. harmala plant extract as a capping agent. UV vis, FTIR, SEM, and XRD were used to determine the structural characteristics. Antibacterial activity was performed against six types of bacterial strains i.e. BetaHaemolytic Streptococci (BHS), Serretia marcescens, Pseudomonas, Shigella, Escherichia coli and Klebsiella pneumonia. Positive control was amikacin and negative control was water. For in vivo antidiabetic activity 25 rats were used in 5 groups. The animals were classified as follows: diabetic; did receive a daily dose of Insulin subcutaneously, diabetic + ZnONPs; did receive single daily oral dose of 10mg/kg in suspension, diabetic + Ag-NPs; did receive daily oral dose of 10mg/kg body weight in suspension, and diabetic + ZnNPs; did receive daily oral dose of 10mg/kg body weight in suspension. A single dosage of Alloxan was used to induce experimental Diabetes mellitus. Blood was taken from the tail vein. A significant reduction in blood sugar levels was noted in rats treated with biologically synthesized nanoparticles. In conclusion, P. harmala nanoparticles showed efficient antidiabetic activity in the rat model of diabetes, suggesting that these could be employed for medical applications in the future.
Page(s):
281-281
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
ZnO NPs
,
antimicrobial
,
Peganumhermala
,
AgNPs
,
Cu NPs
,
Antidiabetic