Development of skin-friendly dermatological water-in-oil emulsion of pomegranate juice. | [Proceedings of Pakistan Academy of Sciences • 2012]

Author(s):

1. Naveed Akhtar: Department of Pharmacy, Islamia University, Bahawalpur, Pakistan

2. Rashida Parveen: Department of Pharmacy, Islamia University, Bahawalpur, Pakistan

3. Barkat Ali Khan: Department of Pharmacy, Islamia University, Bahawalpur, Pakistan; Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, D.I Khan, Pakistan

4. Muhammad Jamshaid: Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan

5. Haroon Khan: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gomal University, D.I. Khan, Pakistan

Abstract:

This study was designed to develop a topical skin-care cream (w/o emulsion) of 4% pomegranate extracts versus its vehicle (the base) as control and evaluate its effects on skin-melanin, skin erythema, skin moisture, skin sebum and TEWL. Concentrated pomegranate (Punica granatum) juice was entrapped in the inner aqueous phase of w/o emulsion. The base containing no extract and a the formulation containing 4% concentrated juice of pomegranate was formulated. The odour was adjusted with few drops of lemon oil. Both the base and the formulation were stored at different storage conditions for a period of four weeks to predict their stability. The stability parameters, i.e., physical stability, centrifugation and pH, were monitored at different time intervals. Both the base and the formulation were applied to the cheeks of 25 healthy human volunteers for a period of 8 weeks. The pharmaceutical stability of creams was achieved from 4 weeks in-vitro study period. Odour disappeared with the passage of time due to volatilization of lemon oil. The and the formulation tended to increase sebum content The results showed a good stability over 4 weeks in vitro observation period of both the base and the formulation and the formulation exhibited bleaching, anti respect to sensory evaluation.

Page(s): 269-278

DOI: DOI not available

Published: Journal: Proceedings of Pakistan Academy of Sciences, Volume: 49, Issue: 4, Year: 2012

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