A Clinical Study of Orally Collagen Intake and Evaluation of the Effects on Human Skin Physiological Properties | [Journal of Pioneering Medical Sciences • 2024]

Author(s):

1. Zehra Betül Ahi: Kazlıçes ̧me R&D Center and Test Laboratories,34956, Tuzla, I ̇stanbul,Türkiye

2. Fatih Arıcan: Kazlıçe¸sme R&D Center and Test Laboratories, 34956, Tuzla, ˙Istanbul, Türkiye; Halavet Food Company, 34956, Tuzla, ˙Istanbul, Türkiye.

3. Aykut Sancaklı: Kazlıçe¸sme R&D Center and Test Laboratories, 34956, Tuzla, ˙Istanbul, Türkiye; Halavet Food Company, 34956, Tuzla, ˙Istanbul, Türkiye.

Abstract:

Today, food supplements have become an indispensable part of a healthy and balanced life, and one of them, collagen supplements especially support the healthy skin structure and have many positive effects on it. The present study is aimed that evaluating the effects of PROFIN® Collagen on healthy skin conditions such as skin hydration, wrinkles, and elasticity. With this aim, we conducted a prospective, single-center, double-blind, randomized, placebo-controlled, 2-arm, parallel-design study to evaluate the effect of 12-week consumption of PROFIN® Collagen Hydrolysate on skin health. A total of 72 healthy female adults, aged between 40 and 65 with at least moderate eye wrinkles were randomized to receive 10 g of PROFIN® Collagen or placebo, once daily for 12 weeks. The majority (73(%)) of participants who took 'Profin Collagen Hydrolysate' had a statistical improvement (decrease) (p<0,05) in mean wrinkle length at Day 42, this improvement continued at the end of the intervention. Furthermore, compared with the placebo group, in placebo group transepidermal water loss results show that there was a significant increase after 6, and 12 weeks of administration, but not in PROFIN® Collagen group. In conclusion, this study demonstrates that PROFIN® Collagen has a positive effect on skin wrinkles and water loss.

Page(s): 150-156

DOI: 10.61091/jpms202413221

Published: Journal: Journal of Pioneering Medical Sciences, Volume: 13, Issue: 2, Year: 2024

Keywords:

Skin health , physiological properties , hydrolysate collagen

References:

[1] Zague V.,de Freitas V.,Rosa V.,de Castro G. A.,Jaeger R. G.,Machado-Santelli G. M. .2011 .Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity. Journal of Medicinal Food, 14(6) : 618-624.

[2] Boelsma E.,Hendriks H. F.,Roza L. .2001 .Nutritional skin care: health effects of micronutrients and fatty acids. The American Journal of Clinical Nutrition, 73(5) : 853-864.

[3] Matsuda N.,Koyama Y. I.,Hosaka Y.,Ueda H.,Watanabe T.,Araya T.,Takehana K. .2006 .Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. Journal of Nutritional Science and Vitaminology, 52(3) : 211-215.

[4] Lee M.,Kim E.,Ahn H.,Son S.,Lee H. .2023 .Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebocontrolled study. Food & Function, 14(7) : 3196-3207.

[5] Mödinger Y.,Schön C.,Vogel K.,Brandt M.,Bielfeldt S.,Wilhelm K. P. .2021 .Evaluation of a Food Supplement with Collagen Hydrolysate and Micronutrients on Skin Appearance and Beauty Effects: A Randomized, Double-Blind, Placebo-Controlled Clinical Study with Healthy Subjects. J Clin Cosmet Dermatol, 4(4) : .

[6] Varani J.,Dame M. K.,Rittie L.,Fligiel S. E.,Kang S.,Voorhees G. J.,J. J. G. J. .2006 .Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. The American Journal of Pathology, 168(6) : 1861-1868.

[7] Lupu M. A.,Gradisteanu Pircalabioru G.,Chifiriuc M. C.,Albulescu R.,Tanase C. .2020 .Beneficial effects of food supplements based on hydrolyzed collagen for skin care. Experimental and Therapeutic Medicine, 20(1) : 12-17.

[8] Duteil L.,Queille-Roussel C.,Maubert Y.,Esdaile J.,Bruno-Bonnet C.,Lacour J. P. .2016 .Specific natural bioactive type 1 collagen peptides oral intake reverse skin aging signs in mature women. J Aging Res Clin Practice, 5(2) : 84-92.

[9] Manríquez J. J.,Gringberg D. M.,Diaz C. N. .2008 .. Wrinkles. BMJ clinical evidence, 1711 : .

[10] Calleja-Agius J.,Muscat-Baron Y.,Brincat M. P. .2007 .Skin ageing. Menopause International, 13(2) : 60-64.

[11] Taeymans J.,Clarys P.,Barel A. O. .2014 .55 use of food supplements as nutricosmetics in health and fitness. Handbook of Cosmetic Science and Technology, 583 : 596.

[12] Moskowitz R. W. .2000 .Role of collagen hydrolysate in bone and joint disease. In Seminars in Arthritis and Rheumatism, 30(2) : 87-99.

[13] Song H.,Li B. .2017 .Beneficial effects of collagen hydrolysate: a review on recent developments. Biomed. J. Sci. Tech. Res, 1 : 458-461.

[14] Musayeva F.,Özcan S.,Kaynak M. S. .2022 .A review on collagen as a food supplement. Journal of Pharmaceutical Technology, 3(1) : 7-29.

[15] Aguirre-Cruz G.,León-López A.,Cruz-Gómez V.,Jiménez-Alvarado R.,Aguirre-Álvarez G. .2020 .Collagen hydrolysates for skin protection: Oral administration and topical formulation. Antioxidants, 9(2) : 181.

[16] Proksch E.,Segger D.,Degwert J.,Schunck M.,Zague V.,Oesser S. .2013 .Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacology and Physiology, 27(1) : 47-55.

[17] Proksch E.,Schunck M.,Zague V.,Segger D.,Degwert J.,Oesser S. .2014 .Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacology and Physiology, 27(3) : 113-119.

[18] Tak Y. J.,Shin D. K.,Kim A. H.,Kim J. I.,Lee Y. L.,Ko H. C.,Lee S. Y. .2021 .Effect of collagen tripeptide and adjusting for climate change on skin hydration in middle-aged women: A randomized, doubleblind, placebo-controlled trial. Frontiers in Medicine, 7 : 608903.

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