A Comprehensive Review on Neurotransmitters, its biological importance and methods of analysis | [The Journal of Microbiology and Molecular Genetics • 2023]

Author(s):

1. Saddam Hussain: Mardan Medical Complex and Teaching Hospital, Mardan Pakistan.

2. Muhammad Iltaf: Ayub Teaching Hospital& Ayub Medical College, Abbottabad, 22020, Pakistan.

3. Esha Nazir: Institute of Molecular Biology and Biotechnology, University of Lahore, City Lahore, 39500, Pakistan

4. Aleeza: Department of Chemistry, Abdul Wali Khan University Mardan, 23200 Mardan, KP, Pakistan.

5. Aisha Hamid: Faculty of Applied Science, Universiti Teknologi MARA(UITM) Shah Alam, Malaysia.

6. Sana Shamim: Dow College of Pharmacy, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences. Ojha campus, Karachi, Pakistan.

7. Izaz ul Islam: Department of Chemistry, Abdul Wali Khan University Mardan, 23200 Mardan, KP, Pakistan.

8. Naqash Khan: Department of Biology, University of Haripur, Haripur, KP, Pakistan.

9. Haleema Bibi: Department of Chemistry, Abdul Wali Khan University Mardan, 23200 Mardan, KP, Pakistan.

10. Syed Jawad Rasheed: Department of Chemistry, University of Sialkot Punjab, Pakistan.

11. Fazal Dad Khan: Department of Chemistry, Abdul Wali Khan University Mardan, 23200 Mardan, KP, Pakistan.

Abstract:

Neurotransmitters being the signaling molecules are crucial for normal brain functions and their imbalance is associated with several mental health diseases. Therefore, precise detection and measurement of these molecules are essential in the diagnosis of different brain disorders and research studies. Although various techniques have been suggested for the analysis and their specific detection and measurement is a challenging task because of their presence in lower concentrations in the central nervous system and mixing with other biochemical substances. This is still an area of ongoing research. The current paper discusses the conventional methods and also the most recent advances and developments in the detection techniques of neurotransmitters such as electrochemical and Nano-object sensing techniques to provide selection guidelines for the diagnosis of diseases and research.

Page(s): 11-41

DOI: 10.52700/jmmg.v4i3.132

Published: Journal: The Journal of Microbiology and Molecular Genetics, Volume: 4, Issue: 3, Year: 2023

Keywords:

electroencephalography , Capillary Electrophoresis , microdialysis , sensing methods , electrochemical sensors

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