Author(s):
1. Muhammad Naveed Umar:
Department of Chemistry, University of Malakand, Pakistan.
Abstract:
Picolylamine template organocatalyst containing only one stereogenic center has been identified for fast aldol reactions (16-48 h). Using 2-5 mol% of (R)- or (S)PicAm-2, cyclohexanone (3.3 equiv) readily undergoes aldol reactions with o-, m-, and p-substituted aromatic aldehyde partners (limiting reagent), including the poor electrophile 4-methylbenzaldehyde (95-99% ee). Furthermore, functionalized cyclic ketone substrates have been converted into four aldol products 9-12 using the lowest catalyst loading (5.0 mol%) to date with the highest yield and enantioselectivity.
Page(s):
88-88
DOI:
DOI not available
Published:
Journal: 4th International Conference of Sciences “Revamped Scientific Outlook of 21st Century, 2025” , November 12,2025, Volume: 1, Issue: 1, Year: 2025
Keywords:
Picolylamine
,
Enantioselctive Aldol Reaction
,
Asymmetric Aldol
,
PicAm2
References:
References are not available for this document.
Citations
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