Xanthine oxidase inhibition of bioactive constituents isolated from Potentilla evestita. | [Journal of Chemical Society of Pakistan • 2016]

Author(s):

1. Abdur-Rauf: Department of Geology, University of Swabi, Anbar, KP, Pakistan

2. Rehan Khan: HEJ Research Institute, Institute of Chemical and Biological sciences, Karachi University Karachi, Pakistan

3. Haroon Khan: Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan

4. Inamullah Khan: Department of Pharmacy, University of Peshawar, Peshawar-25120, Pakistan

5. Muhammad Akram: PCSIR Laboratories complex, Peshawar, KP, Pakistan

Abstract:

The chloroform fraction of Potentilla evestita led to the isolation of three compounds which were characterized as Acacetin 1, Chrysin 2 and Umbelliferone 3. These were tested for their xanthine oxidase inhibition, antimalarial and anticancer potential. When challenged against xanthine oxidase inhibition, outstanding attenuation of the enzyme was observed with IC50 values of 11.92±0.01, 73.74±0.02 and 97.12±0.01 µM respectively. The results of antimalarial assay showed the marked anti-malarial activity of only compound 1 (IC50: 55.14 µM) against Plasmodium falciparum. Compound 1 also exhibited a moderate action against HepG2 human cell lines, while no action was observed for others. In conclusion, all the three compounds demonstrated profound activity against xanthine oxidase, needs further details studies to get molecules of clinical significance.

Page(s): 139-142

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 38, Issue: 1, Year: 2016

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