Topical application of cream containing enriched-schizandrin from Schisandra chinensis fruit exert anti-photoaging efficacy in ultraviolet B-irradicated hairless mice | [Pakistan Journal of Pharmaceutical Sciences • 2023]

Author(s):

1. Mi-Young Yun: Department of Beauty Science, Kwangju Women's University,Gwangju,South Korea

2. Nam-San Kim: Department of Beauty Hair Design, Shinsung University,Cheongsaseo-ro, Seo-gu, Daejeon,South Korea

3. Hwa-Jung Choi: Department of Beauty Art, 142 Bansong Beltway (Bansong-dong), Busan, Youngsan University,,South Korea

Abstract:

Excessive ultraviolet (UV) B irradiation induced skin photoaging. The aim of this study was to evaluate the anti-photoaging efficacy of enriched-schizandrin from Schisandra chinensis fruit in UVB-induced hairless mice. The cream containing enriched-schizandrin from S. chinensis fruit manufactured with another cosmetic ingredient. UVBphotoaged hairless mice topically applied with the cream once a day for 5 weeks. Application of the cream showed normal changes of body weight and food efficiency in the UVB-photoaged hairless mice. The cream application also was decreased interleukin (IL)-1ß, matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expressions and then it inhibited MMP-2 protein expression in UVB-photoaged hairless mice. Furthermore, the cream application inhibited epidermal wrinkle formation and decreased wrinkle depth and it restored to wrinkle thickness and collagen degradation of skin in UVB-photoaged hairless mice. Therefore, the cream could recover photoaging generated by UVB irradiation via downregulation of IL-1ß, MMP-2, MMP-9 mRNA expressions and suppression of expression of MMP-2 proteins.

Page(s): 887-894

DOI: 10.36721/PJPS.2023.36.3.REG.887-894.1

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 36, Issue: 3, Year: 2023

Keywords:

epidermal thickness , Photoaging , Collagen degradation , enrichedschizandrin , hairless mice

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