Thrombotic risk assessment in metastatic and non-metastatic breast cancer patients in Khartoum State, Sudan | [Rawal Medical Journal • 2025]

Author(s):

1. Mohamed Eltaib Elmobark: Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan-45142, Saudi Arabia

Abstract:

Objective: To evaluate the thrombotic tendency among metastatic and non-metastatic breast cancer (BC) patients in Khartoum state. Methodology: This quantitative observational study cases recruited from Khartoum Oncology Specialized center from Dec 2020 to Feb 2021. Convenience sampling method was used for female patients diagnosed with BC (metastatic and non-metastatic) and for healthy controls without BC from the same geographic area. Sociodemographic information, clinical information and laboratory investigations were recorded. The data were analyzed using SPSS version 26. Results: A total of 60 women were included, 32 non metastatic BC, 18 women with metastatic BC and 10 healthy controls. PT was significantly longer among non-metastatic BC patients that used more than 10 treat-ment doses (p=0.01), with significant difference in pla-telets levels between different types of chemotherapy regimen (p=0.009) in metastatic BC. There was sig-nificantly higher level of fibrinogen in metastatic (p=0.017) and non-metastatic (p=0.038) BC with signi-ficantly lower PTT in metastatic (p=0.042) and PT in non-metastatic (p=0.011) when compared to healthy control. Conclusion: Metastatic and non-metastatic BC demo-nstrated a high thrombotic risk.

Page(s): 346-349

DOI: DOI not available

Published: Journal: Rawal Medical Journal, Volume: 50, Issue: 2, Year: 2025

Keywords:

Thrombosis , Metastatic Breast Cancer , nonmetastatic breast cancer

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