Objectives: To assess the relationship between serum lipid profile and some cardiovascular risk factors. Methodology: This cross-sectional study consisted of pregnant and nonlactating women aged 30-55 years, selected by convenience sampling method from who referring health center in Tabriz, Iran from April to May 2017. Anthropometric measurements, blood pressure, fasting serum lipid profile, and dietary intakes of participants were evaluated data was analysis STATA of software. P > 0.1 was taken as significant. Results: Total of 152 non pregnant women were included. Significant positive relationship were found between serum triglyceride (TG) and weight (B = 2.23 and p = 0.032), and between serum TG and total cholesterol (TC) with systolic blood pressure (B = 1.58 and 1.01 with p = 0.059 and 0.096, respectively) and diastolic blood pressure (B = 2.43 and 1.56 with p =0.029 and 0.027, respectively) by multiple-adjusted quantile regression analyses. There were significant correlation between serum TC and daily zinc intake (B = 7.93 and p = 0.003) and between serum HDL-C with age (B = -0.48 and p = 0.029), waist circumference(B = -0.86 and p = 0.025), and waist-hip ratio(B = -72.3 and p = 0.041). No significant relationship were seen between serum lipids and other variables. Conclusions: Serum TG and TC levels were associated with higher blood pressure and HDL-C levels increased with enhancing of central obesity. These findings emphasizes the role of lipid profile as cardiovascular risk factors in women. Effective strategies are necessary for improving dyslipidemia in women.