A Review of 20 Years Research Progression on Prodrug Technology in Inhaled Medications | [Pakistan Journal of Zoology • 2024]

Author(s):

1. Lijuan Liu: Department of Pharmacy and Examination, Henan Vocational College of Nursing, Anyang, 455000, China

2. Jinghang Chen: Department of Respiratory and Critical Care Medicine, The People's Hospital of Anyang City, China

3. Min Wang: Department of Nursing, Henan Vocational College of Nursing,Anyang, 455000, China

4. Wei Li: Department of Medical Technology, Henan Vocational College of Nursing,Anyang, 455000, China

Abstract:

In contrast to systemic administration methods such as oral or injection, inhaled medications are directly administered to the respiratory tract to exert a therapeutic impact, which has clear benefits in the treatment of respiratory illnesses. However, existing inhaled medications are difficult to fulfill clinical prescription demands, and the research and development of novel inhaled pharmaceuticals has significant hurdles due to a lack of comprehensive theoretical and practical experience guidance. Personalized customization of candidate pharmaceuticals to fulfill the needs of inhalation treatment using prodrug technology is now an alternate method of inhalation drug development. This article examines the use of prodrug technology in inhalation administration throughout the last 20 years. These studies discovered that: esterification modification or prodrug technology combined with macromolecular compounds can extend drug pulmonary residence; mannose modification or acid-sensitive bond linkage can achieve drug release in alveolar macrophages; and personalized modified prodrugs can achieve drug release in alveolar macrophages. It is possible to produce physicochemical qualities suited for inhalation administration while reducing medication toxicity. Overall, using prodrug technology may be able to meet the different needs of inhaled drug development and give ideas for how to make new inhaled drugs.

Page(s): 973-987

DOI: 10.17582/journal.pjz/20220813160811

Published: Journal: Pakistan Journal of Zoology, Volume: 56, Issue: 2, Year: 2024

Keywords:

Pharmacokinetics , drug design , Biological pharmacy , Prodrug technology , Inhalation treatment

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