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Xanthine oxidase inhibition by 5-aryledene N,N’-dimethylbarbituric acid derivatives.
Author(s):
1. Khalid Mohammed Khan: HEJ Research Institute of Chemistry International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
2. Momin Khan: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University Karachi, Karachi, Pakistan; Department of Chemistry, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa, Pakistan
3. Aneela Karim: HEJ Research Institute of Chemistry International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
4. Muhammad Taha: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University Karachi, Karachi, Pakistan; Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Bandar Puncak Alam, Selangor, Malaysia
5. Nida Ambreen: HEJ Research Institute of Chemistry International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
6. Anar Gojayev: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University Karachi, Karachi, Pakistan; Baku State University, Baku, Azerbaijan
7. Shahnaz Perveen: Pakistan Council of Scientific & Industrial Research (PCSIR) Laboratories Complex, Peshawar, Pakistan
8. Muhammad Iqbal Choudhary: HEJ Research Institute of Chemistry International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
Abstract:
N,N’-dimethylbarbituric acid derivatives 1-24 were evaluated for their xanthine oxidase (XO) inhibitory activity. Majority of these compounds showed a good to moderate in vitro xanthine oxidase inhibitory activity (IC50 = 20.97 ± 0.29 - 327.0 ± 3.50 µM), while eight compounds were found to be completely inactive. A structure-activity relationship has been discussed, identifying structural features, responsible for varying degree of activity.
Page(s): 496-499
DOI: DOI not available
Published: Journal: Journal of Chemical Society of Pakistan, Volume: 35, Issue: 2, Year: 2013
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