Tocopherol vs tocotrienol (vitamin e) in the management of metabolic syndrome | [Isra Medical Journal • 2023]

Author(s):

1. Saima Rafique: Department of Pharmacology & Therapeutics, Wah Medical College, National University of Medical Sciences, Pakistan

2. Dilshad Ahmed Khan: Department of Pathology, National University of Medical Sciences, Pakistan

3. Kulsoom Farhat: Department of Pharmacology & Therapeutics, Army Medical College, National University of Medical Sciences, Pakistan

4. Mudassar Noor: Department of Pharmacology & Therapeutics, Army Medical College, National University of Medical Sciences, Pakistan

5. Muhammad Asghar Khan: Department of Biological Sciences, National University of Medical Sciences, Pakistan.

6. Mahjabeen Sharif: Department of Pharmacology & Therapeutics, Army Medical College, National University of Medical Sciences, Pakistan

Abstract:

Metabolic syndrome (Met-S) reflects a congregate of metabolic derangements including central obesity, hypertension, insulin resistance, dyslipidemia leading to enhanced risk of developing cardiovascular disease and diabetes. Both tocopherol (TCP) and tocotrienol (T3) have significant role in Met-S. However, it is still unclear regarding better clinical efficacy of either one in management of Met-S. This review compares clinical efficacy of different isomers of tocopherol with tocotrienol in stewardship of Met-S by search of human clinical studies only. Literature search was conducted till 20th May 2023 on PubMed, google scholar, open google search, pak- medinet and Cochrane data-bases. So far evidence revealed that Tocotrienol have been found safer and more beneficial as compared to tocopherol, having great potential in improving diabetes, hypertension and hyperlipidemia in Met-S patients and robust candidate for further future research regarding ameliorating obesity in metabolic syndrome.

Page(s): 74-77

DOI: 10.55282/imj.ra52

Published: Journal: Isra Medical Journal, Volume: 15, Issue: 2, Year: 2023

Keywords:

Obesity , Diabetes , tocopherol , Metabolic syndrome , Dyslipidemias , Tocotrienol

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