UV Spectroscopic Method Development and Validation of Rabeprazole and Levosulpiride in its Bulk and Dosage Form | [Archives of Pharmacy Practice • 2023]

Author(s):

1. Atul Baravkar: Shardabai Pawar Institute of Pharmaceutical Sciences & Research, Shardanagar, Baramati, Pune, Maharashtra, India.

2. Sagar Shinde: Shardabai Pawar Institute of Pharmaceutical Sciences & Research, Shardanagar, Baramati, Pune, Maharashtra, India.

3. Pranali Jadhav: Dr. D. Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune, Maharashtra, India.

4. Vitthal Chopade: Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India.

5. Trupti Dudhgaonkar: Rajarambapu College of Pharmacy, Kasegaon, Karad, Maharashtra.

6. Pradip Lade: Nootan College of Pharmacy, Ghogaon, Kavathemahakal, Sangali, Maharashtra, India.

7. Monika Chavare: Shree Santkrupa College of Pharmacy, Ghogaon, Karad, Maharashtra, India.

Abstract:

Logical strategy is the heart of drug investigation. The current work endeavored to foster precise, straightforward, and delicate techniques for concurrent assessment of rabeprazole and levosulpiride. The overlay range of levosulpiride and rabeprazole display ?max of 288 nm and 282 nm for LEVO and RABE. Standard adjustment bends for levosulpiride and rabeprazole were straight with connection coefficient (r) values in the scope of 0.9998-0.9997 at all chosen frequencies. The precision of the technique was affirmed by recuperation contemplated from the tablet at three distinct degrees of 80%, 100 percent, and 120% recuperation in the scope of 99.97-100 percent legitimizes the exactness of the strategy. Intraday and Interday accuracy was checked for UV strategy, and % RSD was viewed as under 2 for UV technique. The created strategy is a fast device for routine examination of rabeprazole and levosulpiride in the mass and the drug dose structure. Considering the possible general improvement of phony medication portions, the proposed strategy could be important for the quality control research offices in developing countries.

Page(s): 1-5

DOI: 10.51847/ouHxjrpdl7

Published: Journal: Archives of Pharmacy Practice, Volume: 14, Issue: 1, Year: 2023

Keywords:

Method development , UV spectroscopy , Rabeprazole , Levosulpiride , Simultaneous estimation

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