Toxicological investigations of Aloe ferox Mill. extracts using brine shrimp (Artemia salina L.) assay. | [Pakistan Journal of Pharmaceutical Sciences • 2015]

Author(s):

1. Wintola Olubunmi Abosede: Medicinal Plant and Economic Development Research Centre, Department of Botany, University of Fort Hare, Alice, South Africa

2. Arowosegbe Sunday: Medicinal Plant and Economic Development Research Centre, Department of Botany, University of Fort Hare, Alice, South Africa

3. Afolayan Anthony Jide: Medicinal Plant and Economic Development Research Centre, Department of Botany, University of Fort Hare, Alice, South Africa

Abstract:

Cytotoxicity of the extracts of Aloe ferox using brine shrimp was evaluated. Effects of the extracts on hatchability and lethality of brine shrimps were reported in terms of minimum inhibitory concentration and LD50 respectively. The hatching success was in the order: aqueous root extract (39.8%) >aqueous leaf (26.5%) >acetone leaf (13.7%) > ethanol leaf extracts (2.5%). Hatchability in incubations of ethanol and acetone extracts was found to be dose - dependent, with hatching success decreasing as the concentration of the extracts increased. The lethality of extracts was in the order: aqueous leaf extract (4.7%) >aqueous root extract (4.2%) >acetone leaf extract (3.5%) >ethanol root extract (2.6%) > ethanol leaf extract (1.8%) >acetone root extract (0.7%). Mean mortality of nauplii in the control was higher (6.7%) than that of all the extracts. Based on Meyer’s index of toxicity, the acetone leaf extract with LD50 >1.0mg/mL could be considered as non toxic, while the ethanol root extract (LD50A. ferox have consistently exhibited significant pharmaceutical properties in-vitro, the nontoxic extracts could further be exploited for the development of plant-based pharmaceuticals.

Page(s): 635-640

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 28, Issue: 2, Year: 2015

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views