Amino acid sequences of the q and g chains of adult hemoglobin of the patas monkey, Erythrocebus Patas. | [Journal of Chemical Society of Pakistan • 1979]

Author(s):

1. Tetsuo Maita: BioChemistry Department, Nagasaki University School of Medical, Nagasaki, Japan

2. Nobuyuki Aizawa: BioChemistry Department, Nagasaki University School of Medical, Nagasaki, Japan

3. Masanori Kuwahara: BioChemistry Department, Nagasaki University School of Medical, Nagasaki, Japan

4. Kiyoyasu Fukushima: BioChemistry Department, Nagasaki University School of Medical, Nagasaki, Japan

5. Genji Matsuda: BioChemistry Department, Nagasaki University School of Medical, Nagasaki, Japan

6. Morris Goodman: Anatomy Department, Wayne State University School of of Medical, Detroit, Michigan, USA

Abstract:

Globin prepared from hemolglobin of the patas monkey (Erythrocebus patas) was separated into q and g polypeptide chains by chromatography on a CM 52 column. After S-aminoethylation, both chains were digested with trypsin and the amino acid sequences of the tryptic peptides obtained were analyzed. Further, the order of these tryptic peptides in each chain was deduced from their homology with the primary structures of q and g chains of human adult hemolglobin. Comparing the primary structures of the q and g chains of adult hemoglobin of the patas monkey thus obtained with those of human hemoglobin, 5 amino acid substitutions in the q chains and 7 in the g chains were recognized.

Page(s): 5-13

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 1, Issue: 1, Year: 1979

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