The possible counteractive effect of gold nanoparticles against Streptozotocin-induced type 1 Diabetes in young male albino rats. | [Pakistan Journal of Pharmaceutical Sciences • 2016]

Author(s):

1. Manar E Selim: Zoology Department, Faculty of Science, King Saud University, Ain Shams University, Cairo, Egypt

2. Awatif A Hendi: Physics Department, Faculty of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

3. Ebtesam Alfallaj: Physics Department, Faculty of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

Abstract:

The current study was performed to study the effect of biologically synthesised gold nanoparticles (AuNPs) to control hyperglycaemic conditions in streptozotocin (STZ)-induced diabetic mice. In this study, the rats were divided into four groups: Group I normal control rats (non-diabetic, untreated); Group II diabetes-induced rats used as diabetic controls DC (diabetic, untreated). Group III diabetes-induced rats treated with AuNPs DT; Group IV normal rats treated with AuNPs NT. Diabetes was induced by administering an intraperitoneal injection of a freshly prepared solution of STZ (50mg/kg body weight (bw)). The glucose level was significantly increased in the diabetic control rats compared with the controls (P

Page(s): 823-836

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 29, Issue: 3, Year: 2016

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