Author(s):
1. Tuaha Amjad:
Department of Histopathology, University of Health Sciences, Lahore, Pakistan
2. Muhammad Hassan Malik:
Department of Histopathology, University of Health Sciences, Lahore, Pakistan
3. Ghulam Rasool:
Department of Histopathology, University of Health Sciences, Lahore, Pakistan.
4. Shameen Shoaib:
Department of Histopathology, University of Health Sciences, Lahore, Pakistan
Abstract:
The importance of intraoperative consultation through frozen sections can hardly be over-emphasized. The overall accuracy of frozen section diagnosis falls within the range of 92% to 97.98%; however, in brain tissues, the diagnostic accuracy is debatable, considering the artifacts due to ice crystal formation, crushing, and overstretching resulting in impaired histomorphology. On the other hand, reliance on immunohistochemistry on a frozen brain section is even more challenging because of reported interpretational problems. Hence, preserving the histomorphology of brain tissues and optimizing preanalytical variables is crucial for the accurate diagnosis of the patients.
Page(s):
46-49
Published:
Journal: Biomedica, Volume: 39, Issue: 2, Year: 2023
Keywords:
Diagnosis
,
Histomorphology
,
Brain
,
Frozen section
,
fixatives
,
immunnohistochemistry
,
fixation
References:
References are not available for this document.
Citations
Citations are not available for this document.