UV Method Development and Validation of Eperisone Hydrochloride in Bulk and Tablet Formulation. | [RADS Journal of Pharmacy & Pharmaceutical Sciences • 2017]

Author(s):

1. Saima Saleem: Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

2. Saeeda Bano: Plattinum Pharmaceuticals (Pvt.) Ltd, Karachi, Pakistan

3. Safila Naveed: Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

4. M Tanweer Alam: Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

5. Amanullah Khan: Drugs Testing Laboratory Quetta, Health Department Baluchistan, Quetta, Pakistan

6. Ghulam Sarwer: Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

7. Huma Dilshad: Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan

Abstract:

Objective: To develop and validate a UV simple, precise and cost saving method for fast analysis of eperisone hydrochloride in eperisone tablets. Method: The test is developed by using methanol as diluent, performed on UV visible double beam spectrophotometer at range of 200nm-400nm, and found absorbance on maximum wavelength of 260 nm. The test is then validated by using complete parameters of method validation i.e., linearity, precision, selectivity, accuracy, repeatability, robustness, limit of quantitation and detection. The complete procedure is carried out as per United State Results: Calculate individually all parameters of method validation as per standard that should meet the validation criteria. Conclusion: As per above discussion the method is precise and accurate for analysis of eperisone hydrochloride in eperisone hydrochloride tablets.

Page(s): 39-43

DOI: DOI not available

Published: Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 5, Issue: 4, Year: 2017

Keywords:

UV Spectrophotometer , eperisone hydrochloride

References:

[1] ViveksarathiK,RajarajanR,KannanK,ManavalanR, 2012.Dosage form design and evaluation of eperisone hydrochloride matrix film coated extended release tablets,Int J Pharm Pharm Sci 4 575 -81

[2] CabitzaP,RandelliP, 2008.Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study,Eur Rev Med Pharmacol Sci 12 229 -35

[3] ChandanwaleAS,ChopraA,GoregaonkarA,MedhiB,ShahV,GaikwadS, 2011.Evaluation of eperisone hydrochloride in the treatment of acute musculoskeletal spasm associated with low back pain: a randomized, double-blind, placebocontrolled trial,J Postgrad Med 57 278 -

[4] BoseK., 1999.The efficacy and safety of eperisone in patients with cervical spondylosis: results of a randomized, double-blind, placebo-controlled trial,Methods Find Exp Clin Pharmacol 21 209 -14

[5] MelilliB,PiazzaC,VitaleDC,MaranoMR,PecoriA,MattanaP,VolsiVL,IuculanoC,CardìF, 2011.Human pharmacokinetics of the muscle relaxant, eperisone hydrochloride by liquid chromatography-electrospray tandem mass spectrometry,Eur J Drug Metab Pharmacokinet 36 71 -

[6] KhanageSG,MohitePB,JadhavS. Development, 2013.and validation of UV-visible spectrophotometric method for simultaneous determination of eperisone and paracetamol in solid dosage form,Adv Pharm Bull 3 447 -

[7] PatelSK,PatelPU,PatelUJ, 2013.Spectrophotometric estimation of eperisone hydrochloride and Diclofenac sodium in synthetic mixture by QAbsorbance ratio method, -

[8] NeelamDK,SupriyaSM,NitinSP,SwarupSP,SajjalavarlakshmiSR,Sciences, 2013.Development and validation of RP-HPLC method for simultaneous estimation of eperisone hydrochloride and Diclofenac sodium in bulk and pharmaceutical dosage form,International Journal of Pharmaceutical 3 -

[9] BhattDJ,PrajapatiRR,KabaniNF,AkhtarJ, 2013.Development and Validation of RP-HPLC Method for Simultaneous Estimation of Eperisone Hydrochloride and Diclofenac Sodium in Capsule Dosage Form,Pharm Res 5 147 -54

[10] TakamatsuT,YamazakiK,KayanoM,TakenakaF,HasuiM,OhkawaT., 1992.Determination of eperisone in human plasma by gas chromatography-mass spectrometry,J Chromatogr B Biomed Sci Appl 584 261 -6

[11] DingL,WangX,YangZ,ChenY., 2008.UV and IR to identify a degradation product of eperisone hydrochloride in the tablets,J Pharm Biomed Anal 46 282 -7

[12] GuidelineIH, 2005.Validation of analytical procedures: text and methodology Q2 (R1), 11 -2

Citations

Downloads

Views