The protective effect of Echinacea spp. (Echinacea angustifolia and Echinacea purpurea) in a rat colitis model induced by acetic acid. | [Pakistan Journal of Pharmaceutical Sciences • 2014]

Author(s):

1. Zeynal Dogan: Ankara Education and Research Hospital, Gastroenterology Department, Sukriye District, Ulucanlar Street, Altindag, Ankara, Turkey

2. Bilal Ergul: Ankara Education and Research Hospital, Gastroenterology Department, Sukriye District, Ulucanlar Street, Altindag, Ankara, Turkey

3. Murat Sarikaya: Ankara Education and Research Hospital, Gastroenterology Department, Sukriye District, Ulucanlar Street, Altindag, Ankara, Turkey

4. Levent Filik: Ankara Education and Research Hospital, Gastroenterology Department, Sukriye District, Ulucanlar Street, Altindag, Ankara, Turkey

5. Mehmet Alparslan Gonultas: Ankara Education and Research Hospital, Pathology Department, Sukriye District, Ulucanlar Street, Altindag, Ankara, Turkey

6. Sema Hucumenoglu: Ankara Education and Research Hospital, Pathology Department, Sukriye District, Ulucanlar Street, Altindag, Ankara, Turkey

7. Murat Can: Zonguldak Karaelmas University Medical School, Medical Biochemistry, Zonguldak, Turkey

Abstract:

Ulcerative colitis (UC) is a chronic disease that causes an inflammatory condition in the colon. Several cytokines, including tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and transforming growth factor beta (TGF-β) are crucial components of these inflammatory pathways. New therapeutic strategies are needed for improved clinical outcomes in UC and with less adverse effects. That is why alternative therapies such as herbal remedies are increasingly being used with favorable effects in the treatment of UC. Hence, in the present study, we aimed to evaluate the protective effect of Echinacea spp in an experimental rat colitis model induced by acetic acid (AA). Acetic acid was given via a rectal route to induce acute colitis in rats. Rats were placed in four groups: control, Echinacea, Echinacea-colitis and colitis. Tumor necrosis factor alpha, IL-1β and TGF-β levels were measured. Histopathological comparison of the groups was also performed. The disease activity index (DAI) was significantly higher in the colitis group compared to the control, Echinacea and Echinacea-colitis groups (pEchinacea spp. may likely have some therapeutic favorable effects in the management of UC.

Page(s): 1827-1835

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 27, Issue: 6, Year: 2014

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