The protective effect of taurine on cyclophosphamide-induced testicular toxicity in rats | [Pakistan Journal of Pharmaceutical Sciences • 2023]

Author(s):

1. Muhammed Cemil Busı: Department of Medical Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University,Eskisehir,Turkey

2. Semra Yigitaslan: Department of Medical Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University,Eskisehir,Turkey

3. Zuhal Kaltus: Department of Medical Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University,Eskisehir,Turkey

4. Nusin Harmancı: Department of Medical Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University,Eskisehir,Turkey

5. Ezgi Eroglu: Department of Pharmacology, Faculty of Pharmacy, Lokman Hekim University,Ankara,Turkey

6. Orhan Ozatık: Department of Histology and Embriology, Faculty of Medicine, Kutahya Health Sciences University,Kutahya,Turkey

7. Coskun Kaya: Department of Urology, Eskisehir City Hospital,Eskisehir,Turkey

Abstract:

This study aimed to evaluate the protective effect of taurine (TAU) with regard to antioxidant, anti inflammatory and antiapoptotic pathways on cyclophosphamide (CP)-induced testicular toxicity in rats. Forty SpragueDawley male rats were used in this experimental study. The CP group animals received a single dose of 200mg/kg CP on Day 8 intraperitoneally (i.p). The other groups were treated with TAU (75, 150 and 300mg/kg) orally for 14 days prior to and following a single i.p injection of CP. Morphometrical analysis and histological examination of testicular tissue were performed. Serum testosterone, LH and FSH levels were measured in serum using commercial ELISA kits. The testicular injury induced by CP was evaluated in terms of oxidative stress, inflammation and apoptosis with a significant inflammatory and apoptotic response and an insignificant oxidative stress. TAU treatment resulted in improvement in body weight gain, oxidative stress, inflammation and apoptosis, some of which were significant. The improvement was more pronounced for antiapoptotic effect of taurine in the testis of CP-treated animals. It was concluded that TAU may prevent and/or treat the testicular toxicity by ameloirating oxidative stress, inflammation and apoptosis.

Page(s): 1671-1676

DOI: 10.36721/PJPS.2023.36.5.SP.1671-1676.1

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 36, Issue: 5-S, Year: 2023

Keywords:

oxidative stress , Cyclophosphamide , Apoptosis , inflammation , Taurine

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