Traditional Versus Percutaneous Transforaminal Endoforaminal Discectomy effect on the Nervous System Function and Serum LEK, GFAP and PGE-2 in Patients with Senile Lumbar Spinal Stenosis. | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2019]

Author(s):

1. Hejun Chen: Department of Orthopedics Two, Xinjiang Changji Hui Autonomous Prefecture People's Hospital, Xinjiang, 831100-China

2. Junlian Xue: Department of Orthopedics, People's Hospital of Hutubi County, Xinjiang, 831100-China

3. Xinjiang Wu: Department of Orthopedics Two, Xinjiang Changji Hui Autonomous Prefecture People's Hospital, Xinjiang, 831100-China

Abstract:

Objective: To compare the influence of percutaneous transforaminal endoscopic discectomy (PTED) and traditional operation on the nervous system function and the serum leu-enkephalin (LEK), glial fibrillary acidic protein (GFAP) and prostaglandin E-2 (PGE-2) in patients with senile lumbar spinal stenosis. Study Design: Experimental study. Place and Duration of Study: Department of Orthopedics Two, Xinjiang Changji Hui Autonomous Prefecture People's Hospital, Xinjiang, China, from March 2017 to March 2018. Methodology: A total of 146 patients with senile lumbar spinal stenosis were randomly divided into control group and observation group, 73 in each group. Control group underwent traditional operation, while the observation group underwent PTED. General situation of operation, serum LEK, GFAP, PGE-2, American Spinal Injury Association (ASIA) score and Japanese Orthopaedic Association (JOA) score were compared. Results: Intraoperative blood loss in observation group was less than that in control group (p<0.001). Both operation time and length of hospital stay in observation group were shorter than those in control group (both p<0.001). At 24 hours later after operation, both levels of serum LEK and ASIA score in observation group were higher than those in control group (p=0.006 and p<0.001, respectively), and levels of serum GFAP and PGE-2 and JOA score in observation group were all lower than those in control group (all p<0.001). Conclusion: Compared with traditional operation, PTED has the advantages of less intraoperative blood loss, shorter operation time and length of hospital stay, etc. Besides, PTED can effectively reduce serum LEK, BFGF and PGE-2 expression in patients; and dramatically improve their nervous system function and lumbar function.

Page(s): 341-344

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 29, Issue: 4, Year: 2019

Keywords:

Keywords are not available for this article.

References:

[1] MarleME,MoojenWA,ArtsMP,VleggeertLankampCL,Peul WC Leiden - The Hague, 2016.Interspinous process devices versus standard conventional surgical decompression for lumbar spinal stenosis: Cost utility analysis,Spine J 16 702 -10

[2] FörsthP,ÓlafssonG,CarlssonT,FrostA,BorgströmF,FritzellP, 2016.A randomized, controlled trial of fusion surgery for lumbar spinal stenosis,N Engl J Med 374 1413 -23

[3] RagabAA,FyeMA,BohlmanHH, 2003.Surgery of the lumbar spine for spinal stenosis in 118 patients 70 years of age or older,Spine (Phila Pa 28 348 -53

[4] de GraafI,PrakA,Bierma-ZeinstraS,ThomasS,PeulW,KoesB, 2006.Diagnosis of lumbar spinal stenosis: A systematic review of the accuracy of diagnostic tests,Spine (Phila Pa 31 1168 -76

[5] WestermarkP,WestermarkGT,SuhrOB,BergS, 2014.Transthyretin-derived amyloidosis: Probably a common cause of lumbar spinal stenosis,Ups J Med Sci 119 223 -8

[6] OhtoriS,MannojiC,OritaS,YamauchiK,EguchiY,OchiaiN, 2015.Mini-open anterior retroperitoneal lumbar interbody fusion: Oblique lateral interbody fusion for degenerated lumbar spinal kyphoscoliosis,Asian Spine J 9 565 -72

[7] ParkCH,LeeSH, 2013.Effectiveness of percutaneous transforaminal adhesiolysis in patients with lumbar neuroforaminal spinal stenosis,Pain Physician 16 E37 -43

[8] GadjradjPS,HarhangiBS, 2016.Percutaneous transforaminal endoscopic discectomy for lumbar disk herniation,Clin Spine Surg 29 368 -71

[9] HernoA,AiraksinenO,SaariT,LuukkonenM., 1996.Lumbar spinal stenosis: A matched-pair study of operated and non-operated patients,Br J Neurosurg 10 461 -5

[10] GepsteinR,ArinzonZ,AdunskyA,FolmanY., 2006.Decompression surgery for lumbar spinal stenosis in the elderly: Preoperative expectations and postoperative satisfaction,Spinal Cord 44 427 -31

[11] KnaubMA,WonDS,McguireR,HerkowitzHN, 2005.Lumbar spinal stenosis: Indications for arthrodesis and spinal instrumentation,Instr Course Lect 54 313 -9

[12] WenB,ZhangX,LinZ,PengH,ZhengG, 2016.Percutaneous endoscopic transforaminal lumbar spinal canal decompression for lumbar spinal stenosis,Medicine (Baltimore) 95 e5186 -

[13] AhnY., 2014.Percutaneous endoscopic decompression for lumbar spinal stenosis,Expert Rev Med Devices 11 605 -16

[14] JiangCL,YouZD,LuCL,XuD,WangAJ,WangYX, 2000.Leuenkephalin induced by IL-2 administration mediates analgesic effect of IL-2,Neuroreport 11 1483 -5

[15] GuevremontR,PurvesRW, 1999.High field asymmetric waveform ion mobility spectrometry-mass spectrometry: An investigation of leucine enkephalin ions produced by electrospray ionization,J Am Soc for Mass Spectrom 10 492 -501

[16] FraserDD,CloseTE,RoseKL,WardR,MehlM,FarrellC, 2011.Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum,Pediatr Crit Care Med 12 319 -24

[17] WiesmannM,SteinmeierE,MagerkurthO,LinnJ,GottmannD,MisslerU, 2010.Outcome prediction in traumatic brain injury: comparison of neurological status, CT findings, and blood levels of s100B and GFAP,Acta Neurol Scand 121 178 -85

[18] ShehabHA,NassarYH, 2010.Neuromarkers as diagnostic adjuvant to cranial CT in closed traumatic brain injury patients admitted to ICU: A preliminary comparative study,Egypt J Anaesth 26 267 -72

[19] BirrellGJ,McqueenDS, 1993.The effects of capsaicin, bradykinin, PGE2, and cicaprost on the discharge of articular sensory receptors in vitro,Brain Res 611 103 -7

[20] ZimmermannK,ReehPW,AverbeckB. ATP, 2002.can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE2 release in isolated rat dura mater,Pain 97 259 -65

[21] JohanssonT,NarumiyaS,ZeilhoferHU, 2011.Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory pain,Neurosci Lett 495 98 -101

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