Author(s):
1. Muhammad Usman:
Institute of Pharmaceutical Sciences, UVAS, Lahore, Pakistan
Abstract:
Meropenem has been extensively used in the treatment of varieties of infectious diseases. This study was aimed to evaluate and compare the pharmacokinetics of meropenem among Pakistani and South Korean patients as well as to identify the covariates responsible for the interindividual variability on pharmacokinetic parameters. The data of 59 Pakistani patients and 59 South Korean patients was pooled to obtain the working dataset of 118 patients with 596 samples. The population pharmacokinetic model was developed by using NONMEM® software and stepwise covariate modeling (SCM) was done to evaluate the effect of different covariates. Monte Carlo simulations were performed to devise the tailored dose of meropenem. A two-compartmentmodel was found appropriate to describe the data. The values former openem clearance (CL) and inter-compartmental CL (Q) were 12.6 L/h and 6.82 L/h while that of volume of distribution for central compartment (V1) and peripheral compartment (V2) were 16.7 L and 12.1 L respectively. Meropenem CL was not significantly different among Pakistani and South Korean patients however, renal status of the patients estimated by creatinine clearance (CRCL) was the significant covariate for meropenem CL. Monte Carlo simulation of dosage regimens based on renal status revealed that the doses of 400 mg, 600 mg, 800 mg, and 1000 mg administered every 8 hour over 3 h infusion are suitable for the patients with CRCL of 10 mL/min, 25 mL/min, 50 mL/min, and 100 mL/min respectively. The administration of a tailored dose of meropenem q8h over 3 h infusion with consideration of renal status is would achieve the therapeutic outcome.
Page(s):
317-317
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
Pakistan
,
meropenem
,
South Korea
,
population pharmacokinetic
,
Renal status
References:
References are not available for this document.
Citations
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