A Review on hemorrhagic septicemia: The outbreak, pathophysio- logical, diagnosis, treatment and antibiotic resistance | [Pakistan Journal of Medical and Health Sciences • 2020]

Author(s):

1. Jamal Hussaini: Institute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia

2. Noor Masyitah Jumahat: Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital Sungai Buloh,47000 Selangor, Malaysia

3. Negar Shafiei Sabet: Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital Sungai Buloh,47000 Selangor, Malaysia

4. SAEID REZA DOUSTJALAI: Faculty of Medicine, SEGi University, Kota Damansara, Selangor, Malaysia

5. NAZMUL MHM: Graduate School of Medicine Perdana University, Jalan MAEPS Perdana, Selangor 43400, Malaysia

6. NAVINDRA KUMARI PALANISAMY: Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital Sungai Buloh, 47000 Selangor, Malaysia

Abstract:

Hemorrhagic septicemia ( HS) is the most important disease of livestoc k caused by Pasteurella multocida serotype B: 2 (Asian countries) and serotype E:2 (African countries). The outbreak of Pasteurella multocida w orld w idely gave serious economic impact in South and Southeast Asia, Africa and India. Respiratory system plays the main role in the route of trans mission of the HS disease w here the Pasteurella multocida enters the respiratory tract of infected animals thr ough inhalation and passes into the bloodstream thus producing clinical s igns including rising of body temperature, respiratory pain, inflammation, nasal discharge and lethargic. HS disease occurrence in peracute cases typically char acterized as sudden onset w hich leading to rapid death of the infected animal. Diagnosis of HS disease w as mainly based on the clinical sign and sy mptom, post mortem f indings w hich poly merase chain reaction ( PCR) frequently has been used for rapid, sens itive and specific detection of Pasteurella multocida. HS disease w as usually treated w ith a w ide range of antibiotics such as cephalosporins, florfenicol, tetracyclines, and fluoroquinolone. How ever, long ter m usage of the antibiotics resulting in multi- drug resistant against Pasteurella multocida. Thus, several studies on the development of a vaccine for HS disease w as been done and still ongoing now adays in preventing and control HS disease outbreak .

Page(s): 492-494

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 14, Issue: 3, Year: 2020

Keywords:

Antibiotic resistance , Treatment , diagnosis , Pasteurella multocida , Hemorrhagic septicemia

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