Teratogenic effects of bisphenol a exposure during maternal pregnancy and lactation on developing rat pups testes | [Pakistan Armed Forces Medical Journal • 2022]

Author(s):

1. Tooba Khurshid: Islamic International Medical College, Islamabad, Pakistan

2. Shabana Ali: Islamic International Medical College, Islamabad, Pakistan

3. Hussain Ali: National Institute of Health, Islamabad, Pakistan

4. Maleeha Bano: HITEC Institute of Medical Science, Taxila, Pakistan

5. Hira Waqas Cheema: Islamic International Medical College, Islamabad, Pakistan

6. Nabiha Hussain: Islamic International Medical College,Islamabad,Pakistan

Abstract:

Objective: To study the teratogenic effects of Bisphenol A exposure during maternal pregnancy and lactation on the testicular histology of developing rat pups. Design of Study: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy, Islamic International Medical College Rawalpindi in collaboration with the National Institute of Health (NIH) Islamabad Pakistan from Sep 2018 to Sep 2019. Methodology: Eight weeks old, ten pregnant female rats were divided into groups, each comprising five pregnant rats. Pups were born by spontaneous vaginal delivery. Control group A consisted of 15 male rat pups delivered from 5 pregnant rats, fed on a standard diet during pregnancy and lactation till the 21st day. Experimental group B consisted of 15 male rat pups delivered from 5 pregnant female rats who were administered subcutaneous Bisphenol A at a dose of during their pregnancy and lactation till the 21st day. Results: Significant deterioration of quantitative parameters in testes of the experimental group was seen. The seminiferous tubule diameter in group B was 81.99 ± 10.88 compared to group A which was 111.59 ± 8.36. The germinal epithelial height in group B was 10.47 ± 2.34 compared to 30.41 ± 2.43 in group A. The number of Leydig cells in group B was 17 ± 3.45 compared to 47 ± 4.44 in group A. The number of rounded spermatids in group B was 10 ± 3.74 compared to 38 ± 4.02 in group A. Conclusion: Bisphenol A has teratogenic effects on testicular histology of developing rats when exposed to mothers during pregnancy and lactation. This may deteriorate male fertility by adverse effects on spermatogenesis.

Page(s): 986-989

DOI: 10.51253/pafmj.v72i3.6451

Published: Journal: Pakistan Armed Forces Medical Journal, Volume: 72, Issue: 3, Year: 2022

Keywords:

bisphenol A , pregnancy , Lactation , Teratogenic effects , Developing rat testes

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