Abstract:
Curcumin is the main bioactive component in the rhizomes of Curcuma longa and is responsible for its bright yellowish color. Curcumin possesses potent antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial properties. Curcumin is lipophilic and requires an acidic medium for its bioavailability. Nanoparticles are produced to increase the permeability of the curcumin, such as lipospheres, liposomes, solid lipid nanoparticles, etc. Curcumin has been used for centuries in Asia to treat several diseases, such as cancer, cardiovascular disease, diabetes, COVID, etc., due to its pharmacological properties. Curcumin functions by targeting different cell signaling pathways, receptors, cofactors, enzymes, and modulating gene expression. Molecular docking reveals inhibition of melanin stimulating hormone, tyrosinase, tyrosinase-related protein1/2, PKC?, NF?B, IGF-R1, EGFR, PhK,COX, TNF-a, PhK, PGE2, hs-CRP and T cells activity by curcumin. Curcumin decrease levels of IL-17A, IL-17F, IL-22, IL-2, IL-12, IL-22, IL-23 and IFN-gamma. Curcumin induces apoptosis in cancer cells by activating the tumor suppressing gene p53 and inhibiting the PI3K/AKT/mTOR pathway. Curcumin increases antioxidant enzymes like SOD, CAT, GR, etc. Curcumin improves skin disorders like hyperpigmentation, acne vulgaricus, aging, psoriasis, vitiligo, wound healing, and skin cancer.
Page(s):
98-98
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Life Sciences (ICLS-23) 11-12 May 22-23, Volume: 0, Issue: 0, Year: 2023