A comparative study between two different doses of oral pregabalin in attenuating hemodynamic response to laryngoscopy and endotracheal intubation | [Anaesthesia, Pain and Intensive Care • 2020]

Author(s):

1. Veena Patodi: Department of Anesthesiology, JLN Medical College & Hospital, Ajmer, Rajasthan, (India)

2. Ratan Lal Yadav: Department of Anesthesiology, JLN Medical College & Hospital, Ajmer, Rajasthan, (India)

3. Surendra Kumar Sethi: Department of Anesthesiology, JLN Medical College & Hospital, Ajmer, Rajasthan, (India)

4. Neena Jain: Department of Anesthesiology, JLN Medical College & Hospital, Ajmer, Rajasthan, (India)

5. Maina Singh: Department of Anesthesiology, JLN Medical College & Hospital, Ajmer, Rajasthan, (India)

Abstract:

Background: Laryngoscopy and endotracheal intubation is usually associated with exaggerated haemodynamic response. The aim of our study was to compare and evaluate the efficacy of two different doses of oral pregabalin in attenuating hemodynamic response to laryngoscopy and endotracheal intubation along with preoperative level of sedation. Methodology: This prospective randomized study was conducted on one hundred patients, aged 18 to 55 years of either sex belonging to American Society of Anesthesiologists (ASA) physical status I and II, posted for various elective surgical procedures under general anesthesia. They were randomly allocated into two groups ( Group P1 and Group P2) of 50 patients each by computer generated tables of random numbers. Group P1 and P2 received oral pregabalin 75 mg and 150 mg respectively 1 hour prior to induction of anesthesia. Anesthesia technique was standardized and both groups were assessed for hemodynamic changes (HR, SBP, DBP and MAP) after premedication, before and after induction, immediately after intubation and at the end of 1, 3, 5, 10 and 15 min after intubation along with preoperative sedation, side effects or complications. Results: The attenuation in mean HR was comparable between two groups (p > 0.05), with significant attenuation in SBP, DBP and MAP between two groups. (p < 0.05). The preoperative levels of sedation were higher in Group P2 but was statistically insignificant. (p > 0.05) None of the patients had experienced any side effects except dizziness. Conclusion: Oral pregabalin 150 mg when used as a premedication 60 min prior to induction of anesthesia was found to be more effective than oral pregabalin 75 mg in terms of significant attenuation of hemodynamic pressor response to laryngoscopy and endotracheal intubation with acceptable levels of sedation and minimal side effects.

Page(s): 28-35

DOI: DOI not available

Published: Journal: Anaesthesia, Pain and Intensive Care, Volume: 24, Issue: 1, Year: 2020

Keywords:

Laryngoscopy , Pregabalin , Hemodynamic response , Endotracheal intubation

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