Amino glycosides; toxicity of once a day dosing. | [Professional Medical Journal • 2004]

Author(s):

1. Mahboob Ahmed Wagan: Peoples Medical College (PMC), Nawabshah, Pakistan

2. Rashid Ahmed Shaikh: Isra University, Hyderabad, Sindh, Pakistan

3. Syed Saud Hasan: Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Pakistan

4. Shaheen Shah: Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Pakistan

5. Muhammad Baqir Soomro: Department of Anatomy, Islamabad, Pakistan

Abstract:

Aminoglycosides are unique protein synthesis inhibitors and are bactericidal. Instead of three times a day, we gave gentamicin 3 mg/kg once a day, to 10 young patients, whose urine culture report showed sensitivity to gentamicin. They have an average age of 27 ± 6.5 years. The youngest patient was 19 years old and oldest was 37 years old, having normal creatinine clearance. There was no significant (P>0.05) change in renal creatinine clearance before and after 7 days of therapy.

Page(s): 53-56

DOI: DOI not available

Published: Journal: Professional Medical Journal, Volume: 11, Issue: 1, Year: 2004

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