A convenient synthesis of bioactive 5-arylidenebarbiturates. | [Journal of Chemical Society of Pakistan • 2012]

Author(s):

1. Ejaz Ahmed: Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan

2. Ahsan Sharif: Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan

3. Shumaila Chohan: Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan

4. Misbahul Ain Khan: Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan

5. Munawar Ali Munawar: Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan

6. Aleeza Farrukh: Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan

7. Robina Begum: Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan

8. Nighat Afza: Pharmaceutical Research Centre, PCSIR Laboratories Complex, Karachi-75280, Pakistan

9. Muhammad Ashraf: Department of Biochemistry And Biotechnology, The Islamia University, Bahawalpur, Pakistan

10. Shafia Arshad: College of Conventional Medicine, The Islamia University, Bahawalpur, Pakistan

Abstract:

A convenient one pot green chemistry route has been developed for the synthesis of 5-arylidenebarbiturates by way of an acetic acid catalyzed Knoevenagel condensation of a variety of aromatic aldehydes with barbituric acid. The target compounds were obtained in 50-90 % yield and characterized by elemental analysis and different spectral techniques such as IR, NMR and EIMS. All of these were screened for antimicrobial activity.

Page(s): 1305-1311

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 34, Issue: 5, Year: 2012

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