The effect of danofloxacine on in vitro rat myometrium. | [Pakistan Veterinary Journal • 2010]

Author(s):

1. Yasar Akar: Institution of Higher Education, Firat University, Elazig, Turkey

2. Süleyman Demirel Keban: Institution of Higher Education, Firat University, Elazig, Turkey

3. Haki Kara: Elazig School of Health Science, Firat University, Elazig, Turkey

4. Kadir Servi: Department of Pharmacology and Toxicology, Firat University, Elazig, Turkey

5. Hamit Yildiz: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey

Abstract:

The aim of this study was to determine the effect of danofloxacine on in vitro rat myometrium. The myometrium (n=60) obtained from adult female rats. After myometrium showed spontaneous contractions, the contractions were regulated by injecting 0.1mM oxytocin. Then, 5, 10, 20, 40 and 80 μmol danofloxacine was added to isolated organ bath in 10 min intervals, and frequency, peak amplitude and peak area calculations were recorded. With oxytocin supplementation, frequency, peak amplitude and peak area calculations were determined as 6.7±1.0, 1874±107, 1749±68, respectively. With danofloxacine supplementation, frequency and peak amplitude first increased then slowed down in relation to the dose and the peak area decreased in relation to the dose (P

Page(s): 211-214

DOI: DOI not available

Published: Journal: Pakistan Veterinary Journal, Volume: 30, Issue: 4, Year: 2010

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