A rare case of multiple keratoacanthomas of grzybowski | [Journal of Pakistan Association of Dermatologists • 2024]

Author(s):

1. Ricardo Flaminio Rojas López: Departamento de Dermatología, Universidad Autónoma de Bucaramanga,Bucaramanga,Colombia

2. Laura Isabel López Molinares: Médica General, Universidad Libre,Barranquilla,Colombia

3. Mariana Catalina Blanco Restrepo: Programa de Medicina, Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga,Bucaramanga,Colombia

4. Katty Camila Anaya Reyes: Dermatóloga, Universidad Autónoma de Bucaramanga,,Colombia

Abstract:

Generalized eruptive keratoacanthoma (GEKA) of Grzybowski is a rare variant of keratoacanthoma with an unclear pathophysiology. GEKA originates from the hair follicle with a keratotic center and shows histological features of keratoacanthoma. Herein, we report a case of a female 79 years of age with multiple pruritic eruptions over sun-exposed areas, including facial involvement with ectropion. GEKA represents a diagnostic and therapeutic challenge due to the lack of distinct clinical presentation and efficient treatment.

Page(s): 296-300

DOI: DOI not available

Published: Journal: Journal of Pakistan Association of Dermatologists, Volume: 34, Issue: 1, Year: 2024

Keywords:

Abstract , ectropion , eolgtKeratoacanthomas , Hair follicles

References:

[1] Jaber PW,Cooper PH,Greer KE .1993 .Generalized eruptive keratoacanthoma of Grzybowski. J Am Acad Dermatol, 10(93) : 70180-2.

[2] Anzalone CL,Cohen PR .2014 .Generalized eruptive keratoacanthomas of Grzybowski. Int J Dermatol, 10(2) : 131-6.

[3] Liu LQ,Jiao T,Wang JY .2021 .Irreversible blindness in generalized eruptive keratoacanthoma of Grzybowski. Clin Exp Dermatol, 10(7) : 1376-8.

[4] Oakley A,Ng S. .2005 .Grzybowski's generalized eruptive keratoacanthoma: remission with cyclophosphamide. Australas J Dermatol, 00157(2) : 0960-23.

[5] Schwartz RA,Błaszczyk M,Jablonska S M .2002 .Generalized eruptive keratoacanthoma of Grzybowski: follow-up of the original description and 50-year retrospect. Dermatology, 10(4) : 348-52.

[6] Nofal A,Nofal E. .2014 .Generalized eruptive keratoacanthoma of Grzybowski: strict diagnostic criteria are still lacking. Clin Exp Dermatol, 10(1) : 87-8.

[7] Rotola A,Musmeci D,Gentili V,Reale D,Borghi A,Rizzo R,Corazza M. .2019 .Generalized eruptive keratoacanthoma of the Grzybowski type: some considerations on treatment and pathogenesis. Int J Dermatol, 10(12) : e242-e245.

[8] Nofal A,Assaf M,Ghonemy S,Nofal E,Yosef A .2015 .Generalized eruptive keratoacanthoma: a diagnostic and therapeutic challenge. Int J Dermatol, 10(2) : 160-7.

[9] Havenith R,de Vos L,Fröhlich A,Braegelmann C,Sirokay J,Landsberg J,Wenzel J,Bieber T,Niebel D. .2021 .Grzybowski's Generalized Eruptive Keratoacanthomas in a Patient with Terminal Kidney Disease-An Unmet Medical Need Equally Ameliorated by Topical Imiquimod Cream. Lapacho Tea Wraps: A Case Report. Dermatol Ther (Heidelb), 10(2) : 625-38.

[10] Consigli JE,González ME,Morsino R,Guidi A,Chappuis JM,Papa M,Maldonado S M .2000 .Generalized eruptive keratoacanthoma (Grzybowski variant). Br J Dermatol, 03430(4) : 2133-3.

[11] Abbas MN,Tan WS,Kichenadasse G .2021 .Sorafenib-related generalized eruptive keratoacanthomas (Grzybowski syndrome): a case report. J Med Case Rep, 10(1) : 481.

[12] Street ML,White JW .1990 .Multiple keratoacanthomas treated with oral retinoids. J Am Acad Dermatol, 10(90) : 70305-2.

[13] Filippi F,Carpanese MA,Sacchelli L,Loi C,Chessa MA .2022 .Two birds with one stone: Successful treatment with methotrexate in a patient with generalized eruptive keratoacanthoma of Grzybowski and rheumatoid arthritis. Dermatol Ther, 10(11) : .

[14] Mascitti H,De Masson A,Brunet-Possenti F,Bouaziz JD,Laly P,Mourad N,Garrigues JM,Laurent-Roussel S,Cavelier-Balloy B,Moulonguet I,Leschi C,Mourah S,Bagot M,Lebbé C,Basset-Seguin N. .2019 .Successful Treatment of Generalized Eruptive Keratoacanthoma of Grzybowski with Acitretin. Dermatol Ther (Heidelb), 10(2) : 383-8.

[15] Nofal A,Assaf M,Nofal E,Alradi M. .2014 .Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation. J Eur Acad Dermatol Venereol, 10(4) : 397-404.

[16] Rath S,Cowan BJ,Dolman PJ .2014 .Cicatricial ectropion in grzybowski type of multiple eruptive keratoacanthomas. Ophthalmic Plast Reconstr Surg, 10(2) : e42-3.

[17] Haas N,Schadendorf D,Henz BM,Fuchs PG .2002 .Nine-year follow-up of a case of Grzybowski type multiple keratoacanthomas and failure to demonstrate human papillomavirus. Br J Dermatol, 04925(4) : 2133-6.

[18] Kavanagh GM,Marshman G,Hanna MM .1995 .A case of Grzybowski's generalized eruptive keratoacanthomas. Australas J Dermatol, 10(2) : 0960-5.

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