Specrophotometric determination of Indomethacin using partial least Square Method. | [Proceedings of Pakistan Academy of Sciences • 2007]

Author(s):

1. Fouzia Noreen: Applied Chemistry Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Ferozepur Road, Lahore, Pakistan

2. Amina Mumtaz: Applied Chemistry Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Ferozepur Road, Lahore, Pakistan

3. Saima Nazir: Applied Chemistry Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Ferozepur Road, Lahore, Pakistan

4. Tehseen Aman: In-charge Research Cell, Kinnaird College, Lahore, Pakistan

Abstract:

Indomethacin reacts with ammonium oxalate in concentrated sulphuric acid to give a violet colour after heating for 17 min at 80°C having maximum absorbance at 578 nm. The reaction is selective for indomethacin with a 0.05 mg/10 mL as visual limit of identification and provides a basis for a new spectrophotometric determination. The reaction obeys Beer`s Law from 0.05 mg to 4 mg/ 10 mL of indomethacin with inter-day precision of 0.98 %. The quantitative assessment of common interferences and tolerable amount of other drugs were also studied.

Page(s): 173-179

DOI: DOI not available

Published: Journal: Proceedings of Pakistan Academy of Sciences, Volume: 44, Issue: 3, Year: 2007

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