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Aervfuranoside: a new chlorinated dibenzofuran glycoside and other metabolites from the flowers of Aerva javanica.
Author(s):
1. Sara Musaddiq: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan, Department of Chemistry, Kutchehry Campus, The Women University Multan, Multan, Pakistan.
2. Muhammad Saqib Saeed: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
3. Naheed Riaz: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
4. Mamona Nazir: Department of Chemistry, Government Sadiq College Women University, Bahawalpur,Pakistan
5. Tasneem Khatoon: Department of Chemistry, Government Sadiq College Women University, Bahawalpur, Pakistan.
6. Abdul Jabbar: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur,Pakistan.
7. Tayaba Ismail: Department of Chemistry, Government Sadiq College Women University, Bahawalpur, Pakistan.
8. Muhammad Ashraf: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur,Pakistan.
9. Samia Khakwani: Department of Chemistry, Kutchehry Campus, The Women University Multan, Pakistan.
10. Abida Ashraf: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Pakistan.
11. Muhammad Saleem: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Pakistan.
Abstract:
Aervfuranoside (1), a new chlorinated dibenzofuran glycoside together with ten (2-11) known compounds were isolated from ethyl acetate soluble fraction of methanolic extract of the flowers of Aerva javanica. The structures of isolates were elucidated by the combination of 1D (1H and 13C-NMR), 2D (HMQC, HMBC and COSY) NMR spectroscopy and mass spectrometry (FABMS, HRFABMS) or in comparison with the literature data in case of known metabolites. Among these isolates, only compounds 1-3 were evaluated for DPPH free radical scavenging potential and enzyme inhibitory activity against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX) and metallo-ß-lactamase (IMP-1). The test compound 2 exhibited moderate inhibition of the enzyme lipoxygenase with the IC50 value of 53.5 µM.
Page(s): 572-577
DOI: DOI not available
Published: Journal: Journal of Chemical Society of Pakistan, Volume: 39, Issue: 4, Year: 2017
Keywords:
Characterization , enzyme inhibition , Aerva javanica
References:
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