Therapeutic evaluation of intralesional tranexamic acid in higher concentration for treatment of facial melasma | [Journal of Pakistan Association of Dermatologists • 2024]

Author(s):

1. Jyoti: Department of Dermatology and Venereology, Sri Guru Ram Das Institute of Medical Sciences and Research,Amritsar,India

2. Saurabh Sharma: Department of Dermatology and Venereology, Sri Guru Ram Das Institute of Medical Sciences and Research,Amritsar,India

3. Guneet Awal: Department of Dermatology and Venereology, Sri Guru Ram Das Institute of Medical Sciences and Research,Amritsar,India

4. Roopam Bassi: Department of Physiology, Sri Guru Ram Das Institute of Medical Sciences and Research,Amritsar,India

5. Jasleen Kaur: Department of Dermatology and Venereology, Sri Guru Ram Das Institute of Medical Sciences and Research,Amritsar,India

Abstract:

Background Melasma is a chronic relapsing hyperpigmentary disorder. As the entire etiopathogenesis of melasma is not well understood, there are chances of development of new therapeutic modalities. Tranexamic acid (TXA) has been used in a variety of formulations; nevertheless, there are few research, data and opinions regarding the optimal dosage of intralesional TXA in melasma. Methods Total 32 patients were enrolled in our study from January 2023 to June 2023. Injection TXA (0.05 ml) was given intralesionally 1cm apart on entire facial melasma lesion and repeated after every 4 weeks till lesions cleared or a maximum of 6 sessions. Follow up was done at every visit and after 3 months of last session for relapse. Clinical improvement was measured by percentage reduction in mMASI at baseline, at every session and at follow up. Results More than 50% patients showed good to very good response with significant reduction in mMASI from 8th week onwards as compared to baseline. Most of the patients were satisfied with their recovery following therapy and reported no significant adverse effects. Conclusion TXA was found to be efficacious in all types of melasma. Better response was seen in epidermal and mixed types in comparison to dermal melasma. We recommend a dosage of 50mg/ml at monthly intervals as optimal dosage for an effective therapy in all types of melasma.

Page(s): 671-677

DOI: DOI not available

Published: Journal: Journal of Pakistan Association of Dermatologists, Volume: 34, Issue: 3, Year: 2024

Keywords:

Tranexamic acid , Intralesional , Melasma , Melasma , mMASI

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