Ameliorative effect of ethanolic extract of Cichorium intybus on cisplatin-induced nephrotoxicity in rats. | [Pakistan Journal of Scientific and Industrial Research • 2009]

Author(s):

1. Shafaq Noori: Department of Biochemistry, Clinical Biophysics Research Unit, University of Karachi, Karachi, Pakistan

2. Tabassum Mahboob: Department of Biochemistry, Clinical Biophysics Research Unit, University of Karachi, Karachi, Pakistan

Abstract:

In the study of the possible ameliorative effect of the Cichorium intybus vs. cisplatin-induced nephrotoxicity, no sign of toxicity was observed in rats on administration of ethanolic extract of C. intybus (500 mg/kg) with cisplatin (3 mg/kg). Oral administration of C. intybus extract reduced cisplatin-induced nephrotoxicity and also prevented elevated plasma creatinine, urea and nitrate, plasma and tissue MDA levels and restored antioxidant enzymes.

Page(s): 208-216

DOI: DOI not available

Published: Journal: Pakistan Journal of Scientific and Industrial Research, Volume: 52, Issue: 4, Year: 2009

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