The impact of the COVID-19 infection during pregnancy on the placenta and its function-a cross sectional study | [Pakistan Journal of Life and Social Sciences • 2024]

Author(s):

1. R. J. Al-Dahwi: UMHAT "Prof. St. Kirkovich", Stara Zagora, Bulgaria

2. D. Kostadinova-Slavova: UMHAT "Prof. St. Kirkovich", Stara Zagora, Bulgaria

3. M. A. Angelova: UMHAT "Prof. St. Kirkovich", Stara Zagora, Bulgaria

4. G. D. Nikolova: Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, Bulgaria

5. Y. D. Karamalakova: Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, Bulgaria

Abstract:

This research aims at looking into how the coronavirus is likely to influence pregnancies in terms of placental function-important aspects. Global health is faced with unprecedented challenges by the coronavirus pandemic currently happening; pregnant women are particularly at risk because of the bodily changes and potential changes in their immune systems. Study conducted a cross-sectional investigation (March 2022 March 2023) in Stara Zagora, Bulgaria, involving 15 healthy (31.1 ± 6.32 yrs) pregnant women and 20 pregnant women (33.1 ± 4.88 yrs) with SARS-Co-2. We aim to elucidate and understand COVID-19's effects on pregnant women and neonates. Gestational age at delivery of groups were 36 ± 0.8 and 37.6 ± 1.1. The newborn weight (g) was 3090.55 ± 400.1 gr for pregnant women with SARS-Co-2 and 3211±500.6 gr for controls (P<0.09). Usually, COVID-19 patients who needed intensive care are taken to NICU, where outcomes found three patients (15%) patients and two women with (13.3%) control. In this study, we assessed the outcomes of SARS-Co-2 pregnant woman and controls according to pathological placental patterns. We found that the placental weight in the SARS-Co-2 pregnant woman was 465 ± 50.5, larger than the controls (P<0.07). The preterm birth was found for six SARS-Co-2 patients (30%). The neonatal weight was 3390±190.1 g for the SARS-Co-2 pregnant woman versus 3720±110.1 g of controls (P= 0.001). Finally, the placental patterns and relationship between the VAS-QL that occur during late gestational age show evidence of vertical trans-placental SARSCoV-2 transmission and significant influence on perinatal results among newborns, especially with serious conditions, was discussed.

Page(s): 2235-2245

DOI: 10.57239/PJLSS-2024-22.1.00165

Published: Journal: Pakistan Journal of Life and Social Sciences, Volume: 22, Issue: 1, Year: 2024

Keywords:

SARS CoV2 Perinatal Neonatal weight

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