Vasomodulatory effects of semi-purified fractions of garlic aqueous extract on chick chorioallantoic membrane | [Pakistan Journal of Pharmaceutical Sciences • 2021]

Author(s):

1. Heyfa Hadriche-Jarraya: Laboratoire de Neurophysiologie Fonctionnelle et Pathologies, Département des Sciences Biologiques, Faculté des Sciences de Tunis. Campus Universitaire El Manar, Tunis, Tunisie

2. FeridLimam: Laboratoire des Substances Bioactives, Centre de Biotechnologie,Technopole Borj-Cedria, Hammam-Lif, Tunisie,Tunis. Campus Universitaire El Manar, Tunis,Tunisie,

3. Ezzedine Aouani: Laboratoire des Substances Bioactives, Centre de Biotechnologie,Technopole Borj-Cedria, Hammam-Lif, Tunisie,Tunis. Campus Universitaire El Manar, Tunis,Tunisie,

4. Mohamed Amri: Laboratoire de Neurophysiologie Fonctionnelle et Pathologies, Département des Sciences Biologiques, Faculté des Sciences de Tunis. Campus Universitaire El Manar, Tunis, Tunisie

5. Meherzia Mokni: Laboratoire de Neurophysiologie Fonctionnelle et Pathologies, Département des Sciences Biologiques, Faculté des Sciences de Tunis. Campus Universitaire El Manar, Tunis, Tunisie

Abstract:

Allium sativum (As), commonly known as garlic, has been used for a long time, for its therapeutic effects. Recent studies showed the ability of As to modulate vascular activity. The present study aimed to investigate the vasomodulatory effects of aqueous extract of As and to analyse the molecular nature of the active components. Experiments were performed on chick chorioallantoic membrane. Fractions of garlic were directly injected using micropipette on a high vessel density area. Our results clearly indicated that garlic increased permeability and induced vasodilatation of blood vessels and capillaries. These effects were dose-dependent and had been observed just few minutes after the onset of treatment. The active component responsible of these effects, which had a low molecular weight seems to be of peptide nature and appeared different from Dially Sulfide (DAS) and Dially Disulfide (DADS).

Page(s): 943-949

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 34, Issue: 3, Year: 2021

Keywords:

Allium sativum , vasodilatory effect , chorioallantoic membrane

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