Vicissitudes in polyphenolic extract-based high internal phase creams (HIPCs)- effect of storage temperature dependent characteristics | [Pakistan Journal of Pharmaceutical Sciences • 2020]

Author(s):

1. Atif Ali: Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan

2. Naveed Akhtar: Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, the Islamia University of Bahawalpur, Pakistan.

3. Hira Khan: Department of Pharmacy, Abbottabad University of Science and Technology, Havelian, Abbottabad, Pakistan

4. Qazi Adnan Jamil: Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, the Islamia University of Bahawalpur, Pakistan.

5. Sajid Hussain Shah: Department of Environmental Sciences, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan

6. Muhammad Naeem: Department of Pharmacy, Shah Abdul Latif University, Khairpur, Pakistan

7. Muhammad Hassham Hassan Bin Asad: Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan

Abstract:

The purpose of this investigation was to evaluate the vicissitudes in polyphenolic extract- based high internal phase creams (HIPCs) and effect of storage temperature dependent characteristics. Rheological parameters, that is, power law and IPC analysis with its physical characteristics were exploredat different storage temperatures (8°, 25°, 40° and 40° with 75% relative humidity- RH) with different time intervals up to 2 months of newly formulated poly-phenolic extract- based high internal phase cream and its comparison with base. Polyphenolic- based HIPCs showed nonNewtonian- pseudo plastic tendencies in vicissitudes with time and storage temperatures. Data analysis with Power Law and IPC paste was found to fit to all the rheograms. Flow index, shear sensitivity factor, consistency Index and 10 RPM of freshly prepared HIPCs with and without encapsulated polyphenolic extract were found to be 0.5,0.53, 386.4 cP, and 432.9 cP, respectively.The viscosities were fallen with rise in shear stress.There was no change in color, electrical conductivity, liquefaction and phase separation after centrifugation in any sample of polyphenolic extract- based HIPCs and its base. Polyphenolic- based extract HIPCs behaved non-Newtonian- pseudo plastic tendencies and showed stability up to 2 months and can be directed absolutely to shield skin against ultraviolet radiation (UV) intervened oxidative mutilation.

Page(s): 2521-2526

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 33, Issue: 6, Year: 2020

Keywords:

rheology , formulation , storage temperature , high internal phase creams

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views