Author(s):
1. M. H. Rasool:
Department of Microbiology, Government College University Faisalabad, Pakistan
2. M. Saqalein:
Department of Microbiology, Government College University Faisalabad, Pakistan
3. Z. Humyon:
Department of Pharmacy Government College University Faisalabad, Pakistan
4. N. F. Aslam:
Department of Pharmacy Government College University Faisalabad, Pakistan
Abstract:
Immunol® (syrup) (0.65ml/kg), Gen-Xing® (tablet) (7.2mg/kg) and MufarrehYakuuti® (semi-solid) (87mg/kg) were administered orally at normal, 25% (0.82ml/kg, 9mg/kg and 107.5mg/kg) and 50% (0.98ml/kg, 10.8mg/kg and 129mg/kg) increased dose to healthy male rabbits for two weeks. Non-specific and Humoral immune responses were measured through percent Neutrophil Adhesion assay and Haemagglutination Antibody assay against Sheep RBCs respectively. Immunol revealed dose dependent response with maximum percent NA (92.58 ± 2.36 & 97.87±1.31) at 50% increased dose. Effect of drugs on Humoral Immune Response was significantly higher in terms of individual antibody titer and Geometric Mean Titer (GMT) as compared to control. However, Immunol® at 50 % and MufarrehYakuuti® at 25% increased doses showed highest GMT of 1024. GMTs decreased to 50% at 45th day of experiment with highest value of 64. The herbal preparations enhanced the specific and non-specific immunity in rabbits under study. However, Immunol was found to be the best and may be potential candidate for clinical use in future.
Page(s):
248-252
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Science, Volume: 68, Issue: 2, Year: 2016
Keywords:
Immune response
,
Herbal drugs
,
Neutrophil Adhesion
,
Haemagglutination antibody assay and Rabbits
References:
References are not available for this document.
Citations
Citations are not available for this document.