Abstract:
Background: Hypertension is an important risk factor for a variety of cardiovascular, renal and neurological diseases. Given the high prevalence of hypertension in the country, its complications and problems, and the necessity of identifying the risk factors for hypertension Aim: To investigate the association between different ACE gene polymorphisms and hypertension. Methods: This cross-sectional study was performed on patients with primary hypertension who referred to Heart Clinic and Emergency Department of Imam Khomeini Hospital in Ahvaz in 2018. Fourty patients with hypertension were compared with 32 healthy individuals. The addressed factors included age, gender, BMI, systolic and diastolic blood pressure, ACE gene polymorphism and medications. Results: In this study, which was performed on 40 patients with hypertension and 32 healthy individuals, the mean ages of the case and control groups were 50±8.54 and 45.5±7.54 respectively. The BMI in the case group was higher than the control group and there was a statistically significant relationship between BMI and the two groups. The results showed that the mean of SBP and DBP in the case group was much higher than the control group and a significant relationship was found between SBP and DBP in the two groups. Using the independent t-test, a significant difference was observed between the mean age, BMI, SBP and DBP and hypertension of the case and the control groups (P <0.05). Conclusions: The present study showed that primaryhypertension is associated with the ACE polymorphisms.
Page(s):
715-719
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Medical and Health Sciences, Volume: 14, Issue: 1, Year: 2020