Abstract:
Objective: To investigate the predictive e ect of preoperative in ammatory factors on overall survival (OS) in patients diagnosed with gastric adenocarcinoma (GAC). Study Design: Observational study. Place and Duration of Study: Department of General Surgery, Ankara Training and Research Hospital, between January 2011 and October 2020. Methodology: A retrospective examination of 207 patients was made from the demographic, preoperative, and postoperative clinical pathology records of patients diagnosed with GAC. Demographic data, pathological tumor node metastasis (TNM) staging, preoperative in ammatory factors including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and aspartate transaminase (AST)-alanine aminotransaminase (ALT) ratio, red cell distribution width (RDW), and hypoalbuminemia were statistically analysed in respect of the e ect on OS. Results: Overall survival was determined to be signi cantly shorter in patients with age >65 years (p = 0.001), advanced TNM stage (p <0.001), tumor size >4.7 cm (p = 0.007), AST-ALT ratio >1.21 (p = 0.017), and hypoalbuminemia (<35 g / L) (p = 0.018). In Cox regression analysis for all factors a ecting OS, age >65 years (p = 0.002) and TNM stage1B (p = 0.004) and 2A (p = 0.039) were determined as independent predictors of survival. The values of NLR, PLR, and RDW were not statistically signi cant between the groups with and without mortality (p=0.066, p=0.283, p=0.501, respectively). Conclusion: In ammation-based factors including AST-ALT ratio and albumin can help assess prognosis in patients with gastric cancer in standard clinical preoperative tests.
Page(s):
282-287
DOI:
DOI not available
Published:
Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 31, Issue: 3, Year: 2021
Keywords:
gastric cancer
,
albumin
,
overall survival
,
Plateletlymphocyte ratio
,
neutrophillymphocyte ratio
,
In ammationbased factors
,
Tumor nodemetastasis staging
,
Aspartate transaminasealanine aminotransaminase ratio