Author(s):
1. Uzma Chishti:
Department of Obstetrics and Gynaecology, The Aga Khan University Hospital, Karachi, Pakistan
2. Humaira Aziz:
Department of Obstetrics and Gynaecology, The Aga Khan University Hospital, Karachi, Pakistan
3. Imrana Masroor:
Department of Obstetrics and Gynaecology, The Aga Khan University Hospital, Karachi, Pakistan
4. Aliya Begum Aziz:
Department of Obstetrics and Gynaecology, The Aga Khan University Hospital, Karachi, Pakistan
Abstract:
Objective: To compare the radiological peritoneal cancer index (PCI) score to the surgical PCI score for validating it as a non-invasive method to predict surgical outcomes. Study Design: A descriptive study. Place and Duration of the Study: Department of Obstetrics and Gynaecology of the Aga Khan University Hospital, Karachi, Pakistan from September 2021 to May 2022. Methodology: All successive patients diagnosed with advanced-stage ovarian cancer were enrolled in the research. Prior to surgery, the severity of ovarian cancer was evaluated using the Sugarbaker Peritoneal Cancer Index score derived from radiological imaging. The score was compared to the surgical PCI score determined during the surgery. The correlation between the scores and residual tumour status was con rmed. Results: The study included a total of 26 patients. The mean age of patients was 50.17 years, with a standard deviation of 11.04. Five (19.2%) patients underwent surgery rst, whereas 21(80.8%) needed interval debulking surgery after receiving chemotherapy in the neoadjuvant setting. The interclass correlation value among radiological and surgical (PCI) was 0.52, with a 95% con dence interval ranging from 0.17 to 0.75. The Bland-Altman plot displays the agreement amongst the PCI scores, indicating a bias of 1.115 with a 95% con dence interval of 4.61. Surgical exploration revealed zero residual disease in 90% of persons with a PCI score 10. Patients with a PCI score below 10 had also fewer complications. Conclusion: PCI is an e cient means for anticipating the success of surgery and the existence of residual disease without invasive measures. This can be very helpful in deciding the best time for surgery.
Page(s):
1309-1314
Published:
Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 34, Issue: 11, Year: 2024
Keywords:
prognosis
,
Advanced ovarian cancer
,
Peritoneal cancer index
,
Tumour load
,
Carcinomatosis
References:
References are not available for this document.
Citations
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