ABO Blood Group and Haematological parameters in relation to the severity of Plasmodium Falciparum malaria parasitic infection in Sudan | [Bioscience Research • 2022]

Author(s):

1. Yasmeen Gafar: Department of Haematology and Immuno haematology, Faculty of Medical Laboratory Sciences, University of Khartoum -,,Sudan

2. Nusaiba Ahmed: Department of Haematology and Immuno haematology, Faculty of Medical Laboratory Sciences, University of Khartoum -,,Sudan

3. Duaa Elhadi: Department of Haematology and Immuno haematology, Faculty of Medical Laboratory Sciences, University of Khartoum -,,Sudan

4. Wafa saeed: Department of Haematology and Immuno haematology, Faculty of Medical Laboratory Sciences, University of Khartoum -,,Sudan

5. Noha Osama: Department of Haematology and Immuno haematology, Faculty of Medical Laboratory Sciences, University of Khartoum -,,Sudan

6. Moshtaha Ali: Department of Haematology and Immuno haematology, Faculty of Medical Laboratory Sciences, University of Khartoum -,,Sudan

7. Elrashed B. Yasin: Department of Medical Laboratory Technology (MLT), Faculty of Applied Medical Sciences, King Abdulaziz University (KAU),Rabigh,Saudi Arabia

8. Enaam Hussein: Department of Haematology and Immuno haematology, Faculty of Medical Laboratory Sciences, University of Khartoum -,,Sudan

Abstract:

Malaria is an infection caused by intracellular protozoan parasites of the genus Plasmodium, transmitted by the bite of infected Anopheles mosquitoes. With their ability to invade erythrocytes, infection with malaria parasites can lead to many changes in hematological parameters. Many studies reported an association between malaria and parasitic density with a different ABO blood group. This was a comparative cross-sectional study with a sample size of 240. Haematological parameters, Giemsa-stained thick blood films, and ABO blood groups are determined. The frequency of ABO blood groups among study subjects showed that blood group A is most frequent in cases (50.8%), followed by O (31.7%), B (11.7%), and AB (5.8%). The degree of parasitemia of the 120 patients infected with P. falciparum showed that 71 (59.2%) had low (+) intensity, 29 (24.2%) had mild (++), 13 (10.8 %) had moderate (+++), and 7 (5.8%) had the high intensity of infection. The highest degree of parasitemia was found among group A individuals. There was a significant decrease in Hemoglobin concentration, Total White Blood Cells (TWBCs), and lymphocytes count compared with the control group (P<.001). Also, a significant increase in Neutrophil and Red Cell Distribution Width (RDW) compared with the control (P<.001). Patients with high parasitemia significantly noted a reduction in Hb concentration and platelets number (5.9 ±1.5 mg/dl and 41 ±14 cells/µL, respectively). In conclusion, the most frequent blood group in malaria patients was A, followed by O, B, and eventually AB. There was a significant association between blood group type and susceptibility to malaria, developing anemia, and thrombocytopenia.

Page(s): 2111-2117

DOI: DOI not available

Published: Journal: Bioscience Research, Volume: 19, Issue: 4, Year: 2022

Keywords:

Plasmodium falciparum , malaria , hemoglobin , thrombocytopenia , Malaria , Malaria , ABO blood group , parasite density

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