Thiol Disulphide Homeostasis in Patients with Acute Myocardial Infarction (AMI). | [Journal of Pakistan Medical Association • 2018]

Author(s):

1. Havva Sahin Kavakli: Ankara Ataturk Education and Research Hospital, Ankara, Turkey.

2. Ozcan Erel: Biochemistry Department, Ankara Ataturk Education and Research Hospital, Ankara, Turkey

3. Ahmet Ali Sezer: Ankara Ataturk Education and Research Hospital, Ankara, Turkey.

4. Hidir Yilmaz: Ankara Ataturk Education and Research Hospital, Ankara, Turkey.

5. Pinar Koptur: Ankara Ataturk Education and Research Hospital, Ankara, Turkey.

6. Filiz Banu Ethemoglu: Ankara Ataturk Education and Research Hospital, Ankara, Turkey.

7. Ulku Arslan: Emergency Department, 6Department of Anesthesiology and Reanimation, Ankara,

8. Cem Akman: Ankara Ataturk Education and Research Hospital, Ankara, Turkey.

9. Cemile Koca Bicer: Biochemistry Department, Ankara Ataturk Education and Research Hospital, Ankara, Turkey

10. Mustafa Karakus: Emergency Department, 6Department of Anesthesiology and Reanimation, Ankara,

11. BetulOzbek: Biochemistry Department, Yildirim Beyazit University, Yenimahalle Education and Research Hospital, Ankara, Turkey

12. Cenk Firat Uncugil: Biochemistry Department, Yildirim Beyazit University, Yenimahalle Education and Research Hospital, Ankara, Turkey

13. Mustafa Karakus: Biochemistry Department, Ankara Ataturk Education and Research Hospital, Ankara, Turkey

14. Betl zbek: Biochemistry Department, Ankara Ataturk Education and Research Hospital, Ankara, Turkey

Abstract:

Objective: To investigate novel oxidative stress marker thiol disulphide homeostasis in patients with acute myocardial infarction. Methods: The case-control study was conducted at Yildirim Beyazit University, Ankara, Turkey, between October 26, 2015 and January 26, 2016. It comprised patients of ST elevation myocardial infarction, and healthy individuals. Troponin levels, native thiol, total thiol, and disulphide were compared among the groups. Results: Of the 128 subjects, 98(76.5%) were patients and 30(23.43%) were controls. Disulphide levels were lower in the patients compared to the controls (p<0.001).As troponin levels increased, native thiol, total thiol and disulphide levels in patients decreased (p<0.05). Conclusion: Native thiol and total thiol levels may be used as a novel oxidative stres marker in patients with acute myocardial infarction.

Page(s): 1631-1635

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 68, Issue: 11, Year: 2018

Keywords:

oxidative stress , Thiol disulphide homeostasis

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