The Relationship Between the Expression of Tumor Associated Fibroblasts Cav-1 and MCT4 and the Prognosis of Papillary Carcinoma of Breast. | [RADS Journal of Pharmacy & Pharmaceutical Sciences • 2016]

Author(s):

1. Li Cui: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

2. Miaomiao Sun: Department of Pathology, Henan Cancer Hospital, Zhengzhou city, PR China

3. Zhihua Zhao: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

4. Jianping Yang: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

5. Yupeng Zheng: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

6. Lulu He: Department of Pathology, The First Afiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

7. Kuisheng Chen: Department of Pathology, The First Afiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

8. Qingxia Fan: Medical Oncology, eTh First Afiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

Abstract:

Aim: To investigate the potential role of MCT4 in the progress of IMPC in CAFs. Methods: MCT4 and Cav-1 expression in 86 IMPC patients were detected by immunohistochemical LSAB methods and the 105 cases of non specific invasive ductal carcinoma (IDC-NOS) selected as the control. Compared the diefrences of the expressions of them in diefrent issues and analysed the relationship of the main pathological features of the expression of Cav-1 and MCT4 in diefrent ages, tumor stages and hisological grades. Results: The study conformed that the miss expression of Cav-1 on CAFs and the expression of MCT4 up-regulated were related on the poor prognosis of IMPC patients. Conclusion: It suggested that CAFs may be the target of the tumor and can supply the new basis for the treatment of breast cancer.

Page(s): 9-20

DOI: DOI not available

Published: Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 4, Issue: 1, Year: 2016

Keywords:

CAFs , Cav1 , Breast cancer , MCT4

References:

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