The prophylactic effect of nigella sativa against cyclophosphamide in the ovarian follicles of matured adult mice: A preliminary study. | [Journal of Animal and Plant sciences • 2014]

Author(s):

1. S. Kamarzaman: Department of Biomedical Science, Faculty of Allied Health Sciences, International Islamic University Malaysia, IIUM, Malaysia

2. M. Shaban: Department of Biomedical Science, Faculty of Allied Health Sciences, International Islamic University Malaysia, IIUM, Malaysia

3. S. Abdul-Rahman: Department of Biomedical Science, Faculty of Allied Health Sciences, International Islamic University Malaysia, IIUM, Malaysia

Abstract:

This study aims to assess follicle preservation in mature female mice with the provision of Nigella Sativa oil against effects of cyclophosphamide which can cause ovarian follicular loss. Forty-eight ICR mice aged 18 weeks were divided into 3 groups: group I = control, group II = cyclophosphamide-alone (50mg/kg) for 5, 10, 15 and 20 days; and group III = pre-treated with different doses of Nigella sativa oil (0.2ml, 0.5ml and 1.0ml/100g) for 5 days, all by intraperitoneal injection. The histology and the total number of ovarian follicles were studied. Results show that the number of primordial follicles following exposure to cyclophosphamide was significantly reduced (36.33 ± 5.86) as compared to the controls (86.67 ±32.52) at day 10 (p

Page(s): 81-88

DOI: DOI not available

Published: Journal: Journal of Animal and Plant sciences, Volume: 24, Issue: 1, Year: 2014

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