Tackling a deadly global phenomenon: sepsis induced coagulopathy: A narrative review | [Journal of Pakistan Medical Association • 2024]

Author(s):

1. Ainan Arshad: Department of Internal Medicine, Aga Khan University, Karachi, Pakistan

2. Warda Ahmed: Aga Khan University Medical College, Karachi,Pakistan

3. Naureen Rehman: Department of Community Health Sciences, Aga Khan University,Karachi, Pakistan

4. Zehra Naseem: Aga Khan University Medical College, Karachi, Pakistan.

5. Zara Ghos: Aga Khan University Medical College, Karachi, Pakistan.

Abstract:

Sepsis is a potentially fatal illness marked by organ failure and the two main causes of which are shock and disseminated intravascular coagulation. Multi-organ dysfunction in sepsis is mediated by the inflammatory cytokine storm, while sepsis induced coagulopathy is mediated and accelerated by activation of pro-coagulative mechanisms. Regardless of the severity of sepsis, disseminated intravascular coagulation is a potent predictor of mortality in septic patients. Additionally, oxidative stress in sepsis causes renal ischaemia and eventually acute kidney injury. The first and foremost goal is to initiate resuscitation immediately, with treatment mainly focussing on maintaining a balance of coagulants and anticoagulants. A simpler and more universal diagnostic criteria is likely to improve studies on the spectrum associated with sepsis.

Page(s): 959-966

DOI: 10.47391/JPMA.10194

Published: Journal: Journal of Pakistan Medical Association, Volume: 74, Issue: 5, Year: 2024

Keywords:

Anticoagulants , Coagulants , Sepsis induced coagulopathy

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