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Alteration of T, B cells subsets relating to immunosuppression and lymphoid depletion in dogs with spontaneous acute distemper.
Author(s):
1. Yaoqian Pan: College of Animal Science, Henan Institute of Science and Technology, Xinxiang, Henan Province, 453003, China
2. Xingyou Liu: College of Animal Science, Henan Institute of Science and Technology, Xinxiang, Henan Province, 453003, China
3. Liuping Zhang: School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
4. Yuqian Sun: College of Animal Science, Henan Institute of Science and Technology, Xinxiang, Henan Province, 453003, China
5. Ruizhen Li: College of Animal Science, Henan Institute of Science and Technology, Xinxiang, Henan Province, 453003, China
6. Zhike Liu: College of Animal Science, Henan Institute of Science and Technology, Xinxiang, Henan Province, 453003, China
7. Liping Meng: College of Animal Science, Henan Institute of Science and Technology, Xinxiang, Henan Province, 453003, China
Abstract:
A study on dogs with spontaneous acute distemper was carried to investigate the alteration of T and B cells subsets relating to immunosuppression and lymphocytic depletion in lymphoid tissues. CD3, CD4, CD8 and CD45RO antigen expression of T cells and IgG and IgM antibody expression of B cells and distribution of canine distemper virus (CDV) antigen were detected in lymphoid tissues and bone marrow by immunohistochemistry. The results showed the CDV antigen presence in lymphocytes, follicular dendritic cells, interdigitating cells, macrophages and myelocytes. Compared to control group, a moderate loss of CD3+and CD8+ cells (P
Page(s): 449-453
DOI: DOI not available
Published: Journal: Pakistan Veterinary Journal, Volume: 34, Issue: 4, Year: 2014
Keywords:
canine distemper virus , T cells , Subsets , Lymphoid tissue
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